氘代十六烷酸(7,7,8,8-D4)合成路线 （共 11 条）
反应条件
1: 85 percent / NBS; PPh3 / dimethylformamide / 1 h / 0 °C
2: 73 percent / BuLi / tetrahydrofuran; hexane / -78 - 20 °C
3: NBS / acetone; H2O / 0.02 h / -30 °C
4: 97 percent / LiAlH4 / diethyl ether / 20 °C
5: 92 percent / Et3N / CH2Cl2 / 2 h / 20 °C
6: 95 percent / LiAlH4 / diethyl ether / 16 h / 20 °C
7: 97 percent / D2 / RhCl(PPh3)3 / benzene / 36 h
8: 89 percent / aq. HCl / methanol / 24 h / 20 °C
9: IBX / dimethylsulfoxide / 12 h / 20 °C
10: 88 mg / H2SO4; CrO3 / acetone; H2O
View Scheme
参考文献
Abad, Jose-Luis; Serra, Montserrat; Camps, Francisco; Fabrias, Gemma
Journal of Organic Chemistry, 2007 , vol. 72, # 3 p. 760 - 764
反应条件
1: 73 percent / BuLi / tetrahydrofuran; hexane / -78 - 20 °C
2: NBS / acetone; H2O / 0.02 h / -30 °C
3: 97 percent / LiAlH4 / diethyl ether / 20 °C
4: 92 percent / Et3N / CH2Cl2 / 2 h / 20 °C
5: 95 percent / LiAlH4 / diethyl ether / 16 h / 20 °C
6: 97 percent / D2 / RhCl(PPh3)3 / benzene / 36 h
7: 89 percent / aq. HCl / methanol / 24 h / 20 °C
8: IBX / dimethylsulfoxide / 12 h / 20 °C
9: 88 mg / H2SO4; CrO3 / acetone; H2O
View Scheme
参考文献
Abad, Jose-Luis; Serra, Montserrat; Camps, Francisco; Fabrias, Gemma
Journal of Organic Chemistry, 2007 , vol. 72, # 3 p. 760 - 764
反应条件
1: 97 percent / D2 / RhCl(PPh3)3 / benzene / 36 h
2: 89 percent / aq. HCl / methanol / 24 h / 20 °C
3: IBX / dimethylsulfoxide / 12 h / 20 °C
4: 88 mg / H2SO4; CrO3 / acetone; H2O
View Scheme
参考文献
Abad, Jose-Luis; Serra, Montserrat; Camps, Francisco; Fabrias, Gemma
Journal of Organic Chemistry, 2007 , vol. 72, # 3 p. 760 - 764
反应条件
1: 92 percent / Et3N / CH2Cl2 / 2 h / 20 °C
2: 95 percent / LiAlH4 / diethyl ether / 16 h / 20 °C
3: 97 percent / D2 / RhCl(PPh3)3 / benzene / 36 h
4: 89 percent / aq. HCl / methanol / 24 h / 20 °C
5: IBX / dimethylsulfoxide / 12 h / 20 °C
6: 88 mg / H2SO4; CrO3 / acetone; H2O
View Scheme
参考文献
Abad, Jose-Luis; Serra, Montserrat; Camps, Francisco; Fabrias, Gemma
Journal of Organic Chemistry, 2007 , vol. 72, # 3 p. 760 - 764
反应条件
1: 97 percent / LiAlH4 / diethyl ether / 20 °C
2: 92 percent / Et3N / CH2Cl2 / 2 h / 20 °C
3: 95 percent / LiAlH4 / diethyl ether / 16 h / 20 °C
4: 97 percent / D2 / RhCl(PPh3)3 / benzene / 36 h
5: 89 percent / aq. HCl / methanol / 24 h / 20 °C
6: IBX / dimethylsulfoxide / 12 h / 20 °C
7: 88 mg / H2SO4; CrO3 / acetone; H2O
View Scheme
参考文献
Abad, Jose-Luis; Serra, Montserrat; Camps, Francisco; Fabrias, Gemma
Journal of Organic Chemistry, 2007 , vol. 72, # 3 p. 760 - 764
反应条件
1: 95 percent / LiAlH4 / diethyl ether / 16 h / 20 °C
2: 97 percent / D2 / RhCl(PPh3)3 / benzene / 36 h
3: 89 percent / aq. HCl / methanol / 24 h / 20 °C
4: IBX / dimethylsulfoxide / 12 h / 20 °C
5: 88 mg / H2SO4; CrO3 / acetone; H2O
View Scheme
参考文献
Abad, Jose-Luis; Serra, Montserrat; Camps, Francisco; Fabrias, Gemma
Journal of Organic Chemistry, 2007 , vol. 72, # 3 p. 760 - 764
反应条件
1: NBS / acetone; H2O / 0.02 h / -30 °C
2: 97 percent / LiAlH4 / diethyl ether / 20 °C
3: 92 percent / Et3N / CH2Cl2 / 2 h / 20 °C
4: 95 percent / LiAlH4 / diethyl ether / 16 h / 20 °C
5: 97 percent / D2 / RhCl(PPh3)3 / benzene / 36 h
6: 89 percent / aq. HCl / methanol / 24 h / 20 °C
7: IBX / dimethylsulfoxide / 12 h / 20 °C
8: 88 mg / H2SO4; CrO3 / acetone; H2O
View Scheme
参考文献
Abad, Jose-Luis; Serra, Montserrat; Camps, Francisco; Fabrias, Gemma
Journal of Organic Chemistry, 2007 , vol. 72, # 3 p. 760 - 764
反应条件
1: 69 percent / HMPA; BuLi / tetrahydrofuran; hexane / -15 - 0 °C
2: 85 percent / NBS; PPh3 / dimethylformamide / 1 h / 0 °C
3: 73 percent / BuLi / tetrahydrofuran; hexane / -78 - 20 °C
4: NBS / acetone; H2O / 0.02 h / -30 °C
5: 97 percent / LiAlH4 / diethyl ether / 20 °C
6: 92 percent / Et3N / CH2Cl2 / 2 h / 20 °C
7: 95 percent / LiAlH4 / diethyl ether / 16 h / 20 °C
8: 97 percent / D2 / RhCl(PPh3)3 / benzene / 36 h
9: 89 percent / aq. HCl / methanol / 24 h / 20 °C
10: IBX / dimethylsulfoxide / 12 h / 20 °C
11: 88 mg / H2SO4; CrO3 / acetone; H2O
View Scheme
参考文献
Abad, Jose-Luis; Serra, Montserrat; Camps, Francisco; Fabrias, Gemma
Journal of Organic Chemistry, 2007 , vol. 72, # 3 p. 760 - 764
反应条件
1: 69 percent / HMPA; BuLi / tetrahydrofuran; hexane / -15 - 0 °C
2: 85 percent / NBS; PPh3 / dimethylformamide / 1 h / 0 °C
3: 73 percent / BuLi / tetrahydrofuran; hexane / -78 - 20 °C
4: NBS / acetone; H2O / 0.02 h / -30 °C
5: 97 percent / LiAlH4 / diethyl ether / 20 °C
6: 92 percent / Et3N / CH2Cl2 / 2 h / 20 °C
7: 95 percent / LiAlH4 / diethyl ether / 16 h / 20 °C
8: 97 percent / D2 / RhCl(PPh3)3 / benzene / 36 h
9: 89 percent / aq. HCl / methanol / 24 h / 20 °C
10: IBX / dimethylsulfoxide / 12 h / 20 °C
11: 88 mg / H2SO4; CrO3 / acetone; H2O
View Scheme
参考文献
Abad, Jose-Luis; Serra, Montserrat; Camps, Francisco; Fabrias, Gemma
Journal of Organic Chemistry, 2007 , vol. 72, # 3 p. 760 - 764
反应条件
1: 89 percent / aq. HCl / methanol / 24 h / 20 °C
2: IBX / dimethylsulfoxide / 12 h / 20 °C
3: 88 mg / H2SO4; CrO3 / acetone; H2O
View Scheme
参考文献
Abad, Jose-Luis; Serra, Montserrat; Camps, Francisco; Fabrias, Gemma
Journal of Organic Chemistry, 2007 , vol. 72, # 3 p. 760 - 764
