甲基1,3-苯并恶唑-2-基乙酸酯合成路线 （共 6 条）
反应条件
lithium hydroxide T=20°C;
参考文献
Waetzig, Shelli R.; Tunge, Jon A.
Journal of the American Chemical Society, 2007 , vol. 129, # 14 p. 4138 - 4139
反应条件
1: 2-methyl-1,3-benzoxazole With n-butyllithium; diisopropylamine in tetrahydrofuran
T=-78°C; 0.5 h;
2: methyl chloroformate in tetrahydrofuran
T=20°C; Further stages.;
参考文献
Davies; Townsend
Journal of Organic Chemistry, 2001 , vol. 66, # 20 p. 6595 - 6603
反应条件
toluene-4-sulfonic acid
T=160°C; 17 h;
参考文献
Waetzig, Shelli R.; Tunge, Jon A.
Journal of the American Chemical Society, 2007 , vol. 129, # 14 p. 4138 - 4139
反应条件
in ethanol
T=30 - 35°C; 0.5 h;
参考文献
Ostroumov, I. G.; Tsil'ko, A. E.; Maretina, I. A.
Journal of Organic Chemistry USSR (English Translation), 1988 , vol. 24, # 11 p. 2092 - 2095
Zhurnal Organicheskoi Khimii, 1988 , vol. 24, # 11 p. 2321 - 2324
反应条件
1: With KPF6; {RuCl2(1-methyl-4-(1-methylethyl)benzene)}2
T=55°C; 19 h; Inert atmosphere;
2: With water in methanol
参考文献
Ben Ammar, Hamed; Miao, Xiaowei; Fischmeister, Cedric; Toupet, Loic; Dixneuf, Pierre H.
Organometallics, 2010 , vol. 29, # 19 p. 4234 - 4238
反应条件
1: LiOH / 20 °C
2: DCC; DMAP
3: t-BuOK
4: Pd(PPh3)4 / toluene / 2 h / 60 °C
View Scheme
参考文献
Waetzig, Shelli R.; Tunge, Jon A.
Journal of the American Chemical Society, 2007 , vol. 129, # 14 p. 4138 - 4139
