water; adenosine deaminase T=20°C;

1: 57.9 percent / pyridine / 16 h / 45 °C 2: 48 percent / POCl3, diethylaniline / 0.08 h / Heating 3: 1.) ammonia, 2.) NaOMe / 1.) methanol, 120 deg C, 3 h, autoclave, 2.) methanol, reflux, 8 h View Scheme