3-氰基-4,6-二氨基吡啶合成路线 （共 7 条）
反应条件
1: 90percent H2SO4 / 3 h / 60 - 70 °C 2: 2.) 2M aq. NaOH / 1.) 170 deg C, 1.5 d, 2.) 90 deg C, 5 min 3: 57 percent / 50percent HBF4, NaNO2 / 1.) 0 deg C, 2.5 h, 2.) -20 deg C, 16 h 4: SOCl2, DMF / 8 h / Heating View Scheme
参考文献
Rewcastle, Gordon W.; Palmer, Brian D.; Thompson, Andrew M.; Bridges, Alexander J.; Cody, Donna R.; Zhou, Hairong; Fry, David W.; McMichael, Amy; Denny, William A.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 9 p. 1823 - 1835
反应条件
sulfuric acid T=60 - 70°C; 3 h;
参考文献
Rewcastle, Gordon W.; Palmer, Brian D.; Thompson, Andrew M.; Bridges, Alexander J.; Cody, Donna R.; Zhou, Hairong; Fry, David W.; McMichael, Amy; Denny, William A.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 9 p. 1823 - 1835
参考文献
Warner-Lambert Company
Patent: US5654307 A1, 1997 ;
US 5654307 A
反应条件
1: 90percent H2SO4 / 3 h / 60 - 70 °C 2: 2.) 2M aq. NaOH / 1.) 170 deg C, 1.5 d, 2.) 90 deg C, 5 min 3: 57 percent / 50percent HBF4, NaNO2 / 1.) 0 deg C, 2.5 h, 2.) -20 deg C, 16 h View Scheme
参考文献
Rewcastle, Gordon W.; Palmer, Brian D.; Thompson, Andrew M.; Bridges, Alexander J.; Cody, Donna R.; Zhou, Hairong; Fry, David W.; McMichael, Amy; Denny, William A.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 9 p. 1823 - 1835
反应条件
sodium hydroxide; hydrogen; Pd-BaSO4 in methanol
P=2250.2 Torr; 2 h;
参考文献
Metzger, Roland; Oberdoerfer, Juergen; Schwager, Carlos; Thielecke, Wilfried; Boldt, Peter
Liebigs Annalen der Chemie, 1980 , # 6 p. 946 - 953
反应条件
potassium acetate; palladium monocarbide in tetrahydrofuran; hydrogenchloride
参考文献
Warner-Lambert Company
Patent: US6150359 A1, 2000 ;
US 6150359 A
反应条件
sodium hydroxide
5 h; Heating;
参考文献
Metzger, Roland; Oberdoerfer, Juergen; Schwager, Carlos; Thielecke, Wilfried; Boldt, Peter
Liebigs Annalen der Chemie, 1980 , # 6 p. 946 - 953
