1-(6-(噻吩-2-基)吡嗪-3-基)肼合成路线 （共 4 条）
反应条件
hydrazine hydrate
3 h; Heating;
参考文献
Steiner; Gries; Lenke
Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 59 - 63
反应条件
1: phosphorus oxychloride / 4 h / 85 - 95 °C
2: hydrazine hydrate / butan-1-ol / 6 h / 100 °C
View Scheme
参考文献
Wermuth, Camille-Georges; Bourguignon, Jean-Jacques; Schlewer, Gilbert; Gies, Jean-Pierre; Schoenfelder, Angele; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 239 - 249
反应条件
1: 85 percent / N2H4*H2O / ethanol / 7 h / Heating
2: 83 percent / O2NC6H4SO3Na-m, NaOH / H2O; ethanol / 2 h / 100 °C
3: 68 percent / POCl3 / 1.5 h / 135 °C
4: 85 percent / N2H4*H2O / 3 h / Heating
View Scheme
参考文献
Steiner; Gries; Lenke
Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 59 - 63
反应条件
1: 83 percent / O2NC6H4SO3Na-m, NaOH / H2O; ethanol / 2 h / 100 °C
2: 68 percent / POCl3 / 1.5 h / 135 °C
3: 85 percent / N2H4*H2O / 3 h / Heating
View Scheme
参考文献
Steiner; Gries; Lenke
Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 59 - 63
