2-溴-5-氯-3-硝基吡啶合成路线 （共 15 条）
反应条件
hydrogen bromide; bromine; sodium nitrite in water T=-5 - 0°C; 0.75 h;
参考文献
Ding, Zi-Chun; Ma, Xiang; Zhou, Weicheng
Synthetic Communications, 2012 , vol. 42, # 19 p. 2791 - 2796
参考文献
US2003/207910 A1, ;
US 20030207910 A1
反应条件
1: 64 percent / nitric acid; conc. sulfuric acid / 55 - 57 °C 2: 52 percent / NaNO2; conc. HBr; Br2 / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 8 p. 2061 - 2071
反应条件
bromine; phosphorus tribromide
参考文献
Journal of the Chemical Society, , p. 2042,2044
反应条件
iron; acetic acid T=60°C;
参考文献
Ding, Zi-Chun; Ma, Xiang; Zhou, Weicheng
Synthetic Communications, 2012 , vol. 42, # 19 p. 2791 - 2796
参考文献
Zhou, Zhang-Lin; Navratil, James M.; Cai, Sui Xiong; Whittemore, Edward R.; Espitia, Stephen A.; Hawkinson, Jon E.; Tran, Minhtam; Woodward, Richard M.; Weber, Eckard; Keana, John F.W.
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 8 p. 2061 - 2071
参考文献
Berrie et al.
Journal of the Chemical Society, 1952 , p. 2042,2044
反应条件
1: iron-turnings; acetic acid 2: aqueous HCl View Scheme
参考文献
Berrie et al.
Journal of the Chemical Society, 1952 , p. 2042,2044
反应条件
1: iron; acetic acid / 60 °C 2: pyridine / dichloromethane / 1 h / 0 - 20 °C 3: tetraphosphorus decasulfide / toluene / 0.5 h / 110 °C View Scheme
参考文献
Synthetic Communications, , vol. 42, # 19 p. 2791 - 2796
反应条件
1: aqueous ethanol
2: SnCl2; concentrated aqueous HCl
View Scheme
参考文献
Takahashi et al.
Chemical and Pharmaceutical Bulletin, 1959 , vol. 7, p. 602
