1: C9H16N2*C3H2F6O2 With potassium tert-butylate; tetrabutyl-ammonium chloride in N,N-dimethyl-formamide T=-30°C; 0.5 h; 2: 4-dimethylamino-benzaldehyde in N,N-dimethyl-formamide T=-30°C; 1.5 h;

1: trifluoromethane acid With potassium dimsylate; N,N-dimethyl-formamide in dimethyl sulfoxide T=-40°C; Metallation; deprotonation; addition; 0.5 h; 2: 4-dimethylamino-benzaldehyde With N,N-dimethyl-formamide in dimethyl sulfoxide T=-40 - 0°C; Addition; trifluoromethylation;

1: 2,2,2-trifluoroethane-1,1-diol With potassium tert-butylate in N,N-dimethyl-formamide T=-50°C; 0.583333 h; 2: 4-dimethylamino-benzaldehyde in N,N-dimethyl-formamide T=-50°C; 1 h;

T=120°C; 6 h;

zinc; NiCl2((PPh3)P)2; triphenylphosphine in N,N-dimethyl-formamide In a sealed tube;

sodium tetrahydroborate in isopropyl alcohol 16 h; Ambient temperature;

sodium azide; sodium perchlorate in water; acetonitrile T=25°C; Rate constant;

1: 100 percent / CsF / 1,2-dimethoxy-ethane / 3 h 2: 95 percent / aq. HCl / tetrahydrofuran / 2 h / 20 °C View Scheme