5'-溴螺[1,3-二噁戊环并-2,3'-吲哚]-2'(1'H)-酮合成路线 （共 4 条）
反应条件
toluene-4-sulfonic acid in toluene 5 h; Reflux;
参考文献
WAYNE STATE UNIVERSITY; DUTTA, Aloke, K.
Patent: WO2014/85600 A1, 2014 ;
Location in patent: Paragraph 000163 ;
反应条件
1: sodium sulfate; hydrogenchloride; hydroxylamine hydrochloride / water / 2 h / 85 °C 2: sulfuric acid / 0.5 h / 60 - 90 °C 3: toluene-4-sulfonic acid / toluene / 5 h / 130 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 21, # 9 p. 2663 - 2670
反应条件
1: sulfuric acid / 0.5 h / 60 - 90 °C 2: toluene-4-sulfonic acid / toluene / 5 h / 130 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 21, # 9 p. 2663 - 2670
反应条件
1.1: bis-triphenylphosphine-palladium(II) chloride / ethylene glycol dimethyl ether / 0.25 h / 20 °C / |Inert atmosphere 1.2: Suzuki Coupling / 2 h / |Reflux; |Inert atmosphere 2.1: hydrogenchloride / methanol / 4 h / |Inert atmosphere; |Reflux View Scheme
参考文献
Tetrahedron, , vol. 68, # 47 p. 9750 - 9762,13
