7-甲基-4(3h)-喹唑啉酮合成路线 （共 12 条）
反应条件
1: With methanol; acetic acid T=20°C; 0.0833333 h; 2: With bromine T=20°C; 3 h;
参考文献
AMGEN INC.
Patent: WO2008/153947 A2, 2008 ;
Location in patent: Page/Page column 43; 58 ;
WO 2008/153947 A2
参考文献
HANMI PHARM CO., LTD.; BAE, In Hwan; SON, Jung Beom; HAN, Sang Mi; KWAK, Eun Joo; KIM, Ho Seok; SONG, Ji Young; BYUN, Eun Young; JUN, Seung Ah; AHN, Young Gil; SUH, Kwee Hyun
Patent: WO2013/100632 A1, 2013 ;
Location in patent: Page/Page column 50 ;
参考文献
Kulkarni, Shridhar S.; Singh, Satyakam; Shah, Janki R.; Low, Woon-Kai; Talele, Tanaji T.
European Journal of Medicinal Chemistry, 2012 , vol. 50, p. 264 - 273
反应条件
T=110°C; 4 h; Sealed tube;
参考文献
Glenmark Pharmaceuticals S.A.; GHARAT, Laxmikant Atmaram; Banerjee, Abhisek; Khairatkar-Joshi, Neelima; Kattige, Vidya Ganapati
Patent: US2013/210844 A1, 2013 ;
Location in patent: Paragraph 0438; 0439 ;
反应条件
1: tin; hydrochloric acid
2: potassium hydroxide; water
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参考文献
Niementowski
Journal fuer Praktische Chemie (Leipzig), 1889 , vol. <2> 40, p. 12
反应条件
1: potassium hydroxide; water
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参考文献
Niementowski
Journal fuer Praktische Chemie (Leipzig), 1889 , vol. <2> 40, p. 12
反应条件
1: oxalyl dichloride / toluene / 2 h / 0 - 26 °C
2: ammonium hydroxide / tetrahydrofuran / 4 h / 0 - 26 °C
3: iron; ammonium chloride / ethanol; water / 2 h / |Reflux
4: 4 h / 110 °C / |Sealed tube
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参考文献
Glenmark Pharmaceuticals S.A.; GHARAT, Laxmikant Atmaram; Banerjee, Abhisek; Khairatkar-Joshi, Neelima; Kattige, Vidya Ganapati
Patent: US2013/210844 A1, 2013 ;
反应条件
1: iron; ammonium chloride / ethanol; water / 2 h / |Reflux
2: 4 h / 110 °C / |Sealed tube
View Scheme
参考文献
Glenmark Pharmaceuticals S.A.; GHARAT, Laxmikant Atmaram; Banerjee, Abhisek; Khairatkar-Joshi, Neelima; Kattige, Vidya Ganapati
Patent: US2013/210844 A1, 2013 ;
反应条件
1: ammonium hydroxide / tetrahydrofuran / 4 h / 0 - 26 °C
2: iron; ammonium chloride / ethanol; water / 2 h / |Reflux
3: 4 h / 110 °C / |Sealed tube
View Scheme
参考文献
Glenmark Pharmaceuticals S.A.; GHARAT, Laxmikant Atmaram; Banerjee, Abhisek; Khairatkar-Joshi, Neelima; Kattige, Vidya Ganapati
Patent: US2013/210844 A1, 2013 ;
参考文献
Bogert; Hoffman
Journal of the American Chemical Society, 1905 , vol. 27, p. 1301
