反应条件
1: 1-(tert-butoxy-carbonyl)piperidine With N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in diethyl ether; hexane
T=-78°C;
2: With C13H28N2O; sec.-butyllithium in diethyl ether; hexane
T=-78 - -30°C;
3: dimethyl sulfate in diethyl ether; hexane
T=-78 - 20°C; 18 h; optical yield given as percent eeenantioselective reaction;
参考文献
Coldham, Iain; Raimbault, Sophie; Whittaker, David T. E.; Chovatia, Praful T.; Leonori, Daniele; Patel, Jignesh J.; Sheikh, Nadeem S.
Chemistry - A European Journal, 2010 , vol. 16, # 13 p. 4082 - 4090
