2-(3-氟-5-苯基苯基)丙酸合成路线 （共 3 条）
反应条件
sodium hydroxide in methanol
1 h; Heating;
参考文献
Tamura, Yasumitsu; Yoshimoto, Yoshihiko; Kunimoto, Katsutoshi; Tada, Shin-ichi; Matsumura, Shingo; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 43 - 47
反应条件
1: 75 percent / aq. NaOH, n-Bu4N(HSO4) / CH2Cl2 / 4 h / Ambient temperature
2: 68 percent / aq. NaOH / methanol / 1 h / Heating
View Scheme
参考文献
Tamura, Yasumitsu; Yoshimoto, Yoshihiko; Kunimoto, Katsutoshi; Tada, Shin-ichi; Matsumura, Shingo; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 43 - 47
反应条件
1: concd HCl / methanol / 4 h / Heating
2: HCl / 2 h / Heating
3: 1.) a) 43percent HBF4, b) aq. NaNO2 / 1.) 0-5 deg C, a) 10 min, b) 20 min, 2.) 80-140 deg C, 0.5 h
4: 75 percent / aq. NaOH, n-Bu4N(HSO4) / CH2Cl2 / 4 h / Ambient temperature
5: 68 percent / aq. NaOH / methanol / 1 h / Heating
View Scheme
参考文献
Tamura, Yasumitsu; Yoshimoto, Yoshihiko; Kunimoto, Katsutoshi; Tada, Shin-ichi; Matsumura, Shingo; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 43 - 47
