4[(三甲基硅基)乙炔基]苯胺合成路线 （共 15 条）
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide in diethylamine; N,N-dimethyl-formamide T=25°C; 5 h;
参考文献
Erdelyi; Gogoll
Journal of Organic Chemistry, 2001 , vol. 66, # 12 p. 4165 - 4169
反应条件
TPGS–750–M; ammonium chloride; zinc in water T=20°C; 6 h; Green chemistry; chemoselective reaction;
参考文献
Kelly, Sean M.; Lipshutz, Bruce H.
Organic Letters, 2014 , vol. 16, # 1 p. 98 - 101
反应条件
cesium fluoride in tetrahydrofuran T=20°C; Silylation; 1.5 h;
参考文献
Ishizaki, Miyuki; Hoshino, Osamu
Tetrahedron, 2000 , vol. 56, # 45 p. 8813 - 8819
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triphenylphosphine in diethylamine; N,N-dimethyl-formamide T=120°C; Sonogashira reaction; 0.416667 h; microwave irradiation;
参考文献
Erdelyi; Gogoll
Journal of Organic Chemistry, 2001 , vol. 66, # 12 p. 4165 - 4169
反应条件
1: triethylamine; tetrakis(triphenylphosphine) palladium(0); copper(l) iodide / tetrahydrofuran / 20 °C 2: zinc; ammonium chloride; TPGS–750–M / water / 6 h / 20 °C / |Green chemistry View Scheme
参考文献
Organic Letters, , vol. 16, # 1 p. 98 - 101
反应条件
zinc trifluoromethanesulfonate
参考文献
Organic Letters, , vol. 11, # 13 p. 2796 - 2799
反应条件
1: With hydrogenchloride; sodium nitrite T=0 - 5°C; 0.75 h; 2: With potassium iodide in dichloromethane; water T=20°C; 4 h; Further stages.;
参考文献
Aujard; Baltaze; Baudin; Cogne; Ferrage; Jullien; Perez; Prevost; Lin Mao Qian; Ruel
Journal of the American Chemical Society, 2001 , vol. 123, # 34 p. 8177 - 8188
反应条件
potassium hydroxide in tetrahydrofuran; methanol Reflux;
参考文献
Li, Zhanxian; Zhao, Wanying; Zhang, Yuna; Zhang, Lifeng; Yu, Mingming; Liu, Jinxia; Zhang, Hongyan
Tetrahedron, 2011 , vol. 67, # 37 p. 7096 - 7100
反应条件
1: dichloromethane / 20 °C / |Inert atmosphere 2: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 48 h / 35 °C / |Inert atmosphere View Scheme
参考文献
Neil, Emily R.; Funk, Alexander M.; Yufit, Dmitry S.; Parker, David
Dalton Transactions, 2014 , vol. 43, # 14 p. 5490 - 5504
反应条件
1: NaOH / ethanol; tetrahydrofuran / 0.5 h 2: 77 percent / PdCl2(PPh3)2, CuI, Et3N / 16 h / Ambient temperature 3: 1.) NaNO2, conc. aq. HCl, 2.) KI / 1.) 0 deg C, 45 min, 2.) water, RT, overnight 4: 94 percent / PdCl2(PPh3)2, CuI, Et3N / 16 h / Ambient temperature View Scheme
参考文献
Lavastre, Olivier; Ollivier, Laurence; Dixneuf, Pierre H.; Sibandhit, Sourisak
Tetrahedron, 1996 , vol. 52, # 15 p. 5495 - 5504
