4-[(三甲基硅基)乙炔基]苄腈合成路线 （共 22 条）
反应条件
potassium carbonate in methanol; dichloromethane
参考文献
Dirk, Shawn M.; Tour, James M.
Tetrahedron, 2003 , vol. 59, # 3 p. 287 - 293
反应条件
N-chloro-succinimide; tetrabutyl ammonium fluoride in N,N-dimethyl-formamide T=20°C; 22 h; Inert atmosphereSchlenk technique; Reagent/catalystSolventTimeConcentration;
参考文献
Chemistry - A European Journal, , vol. 20, # 10 p. 2746 - 2749
反应条件
water; triethylamine; triphenylphosphine; [RhCl(η2:η2-cycloocta-1,5-diene)]2 in tetrahydrofuran T=160°C; P=51485.6 Torr; 4 h;
参考文献
Takeuchi, Ryo; Yasue, Hiroyuki
Journal of Organic Chemistry, 1993 , vol. 58, # 20 p. 5386 - 5392
反应条件
methanol; potassium carbonate T=20°C; 3 h;
参考文献
Wu, Wanhua; Wu, Wenting; Ji, Shaomin; Guo, Huimin; Song, Peng; Han, Keli; Chi, Lina; Shao, Jingyin; Zhao, Jianzhang
Journal of Materials Chemistry, 2010 , vol. 20, # 43 p. 9775 - 9786
反应条件
1: 89 percent / K2CO3; MeOH / CH2Cl2 / 0.5 h / 20 °C 2: 49 percent / CuI; triethylamine; PdCl2(PPh3)2 / benzene / 16 h / 70 °C View Scheme
参考文献
Dixon, Sally; Whitby, Richard J.
Tetrahedron Letters, 2006 , vol. 47, # 46 p. 8147 - 8150
反应条件
1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C 2.1: bis[2-(N,N-dimethylamino)ethyl] ether; ethylmagnesium bromide / tetrahydrofuran / 2.25 h / 20 °C 2.2: 6 h / 20 °C View Scheme
参考文献
Vechorkin, Oleg; Godinat, Aurelien; Scopelliti, Rosario; Hu, Xile
Angewandte Chemie - International Edition, 2011 , vol. 50, # 49 p. 11777 - 11781
反应条件
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); diisopropylamine in toluene
T=20°C; Sonogashira coupling; Inert atmosphere;
参考文献
Fang, Jing-Kun; An, De-Lie; Wakamatsu, Kan; Ishikawa, Takeharu; Iwanaga, Tetsuo; Toyota, Shinji; Akita, Shin-Ichi; Matsuo, Daisuke; Orita, Akihiro; Otera, Junzo
Tetrahedron, 2010 , vol. 66, # 29 p. 5479 - 5485
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine
T=20°C; 3 h;
参考文献
Feng, Yi-Si; Xie, Chuan-Qi; Qiao, Wen-Long; Xu, Hua-Jian
Organic Letters, 2013 , vol. 15, # 4 p. 936 - 939
反应条件
zinc(II) chloride in 1,4-dioxane
T=100°C; 1.5 h;
参考文献
Andreev, Aleksey A.; Konshin, Valeri V.; Komarov, Nikolai V.; Rubin, Michael; Brouwer, Chad; Gevorgyan, Vladimir
Organic Letters, 2004 , vol. 6, # 3 p. 421 - 424
反应条件
zinc trifluoromethanesulfonate; triethylamine in dichloromethane
T=23°C; 12 h;
参考文献
Rahaim Jr., Ronald J.; Shaw, Jared T.
Journal of Organic Chemistry, 2008 , vol. 73, # 7 p. 2912 - 2915
