5-甲氧基-2-甲基-1H-吲哚-3-乙酸甲酯合成路线 （共 12 条）
反应条件
sodium in benzyl alcohol
参考文献
Cell Pathways, Inc.; University of Arizona
Patent: US5721347 A1, 1998 ;
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; potassium hexamethylsilazane 1.) THF; Multistep reaction;
参考文献
Gallant, Michel; Dufresne, Claude; Gareau, Yves; Guay, Daniel; Leblanc, Yves; Prasit, Petpiboon; Rochette, Chantal; Sawyer, Nicole; Slipetz, Deborah M.; Tremblay, Nathalie; Metters, Kathleen M.; Labelle, Marc
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 19 p. 2263 - 2268
反应条件
1.1: sodium t-butanolate / tetrahydrofuran / 0.42 h / 0 - 5 °C 1.2: 20 °C 2.1: trimethyl-tin hydroxide / 1,2-dichloro-ethane / 0.5 h / 130 °C / |Inert atmosphere; |Microwave irradiation View Scheme
参考文献
Liedtke, Andy J.; Marnett, Lawrence J.; Kim, Kwangho; Stec, Donald F.; Sulikowski, Gary A.
Tetrahedron, 2012 , vol. 68, # 48 p. 10049 - 10058,10
Title/Abstract Full Text Show Details
Liedtke, Andy J.; Kim, Kwangho; Stec, Donald F.; Sulikowski, Gary A.; Marnett, Lawrence J.
Tetrahedron, 2012 , vol. 68, # 48 p. 10049 - 10058
反应条件
1.1: sodium t-butanolate / tetrahydrofuran / 0.42 h / 0 - 5 °C 1.2: 20 °C 2.1: trimethyl-tin hydroxide / 1,2-dichloro-ethane / 0.5 h / 130 °C / |Inert atmosphere; |Microwave irradiation View Scheme
参考文献
Liedtke, Andy J.; Marnett, Lawrence J.; Kim, Kwangho; Stec, Donald F.; Sulikowski, Gary A.
Tetrahedron, 2012 , vol. 68, # 48 p. 10049 - 10058,10
Title/Abstract Full Text Show Details
Liedtke, Andy J.; Kim, Kwangho; Stec, Donald F.; Sulikowski, Gary A.; Marnett, Lawrence J.
Tetrahedron, 2012 , vol. 68, # 48 p. 10049 - 10058
反应条件
1: 2-(5-methoxy-2-methyl-1H-indol-3-yl)acetic acid With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine in dichloromethane
T=20°C; 0.0833333 h;
2: methanol in dichloromethane
T=20°C;
参考文献
Liedtke, Andy J.; Marnett, Lawrence J.; Kim, Kwangho; Stec, Donald F.; Sulikowski, Gary A.
Tetrahedron, 2012 , vol. 68, # 48 p. 10049 - 10058,10
Title/Abstract Show Details
Liedtke, Andy J.; Kim, Kwangho; Stec, Donald F.; Sulikowski, Gary A.; Marnett, Lawrence J.
Tetrahedron, 2012 , vol. 68, # 48 p. 10049 - 10058
反应条件
sulfuric acid in methanol; ethyl acetate
参考文献
Eli Lilly and Company
Patent: US5578634 A1, 1996 ;
US 5578634 A
反应条件
hydrogenchloride in 1,4-dioxane; methanol
参考文献
Bitonti; Alan J.; McDonald; Ian A.; Salituro; Francesco G.; Whitten; Jeffrey P.; Jarvi; Esa T.; Wright; Paul S.
Patent: US5877202 A1, 1999 ;
反应条件
in methanol
T=0 - 60°C;
参考文献
Chowdhury, Morshed A.; Huang, Zhangjian; Abdellatif, Khaled R.A.; Dong, Ying; Yu, Gang; Velazquez, Carlos A.; Knaus, Edward E.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 19 p. 5776 - 5780
反应条件
phosphorus trichoride in dichloromethane
12 h; Ambient temperature;
参考文献
Baccolini, Grazieno; Dalpozzo, Renato; Todesco, Paolo E.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 971 - 974
反应条件
1.1: sodium methylate / methanol / 72 h / Inert atmosphere
1.2: pH Ca. 1 / Inert atmosphere
2.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine / Inert atmosphere
2.2: Inert atmosphere
View Scheme
参考文献
Scholz, Matthias; Blobaum, Anna L.; Marnett, Lawrence J.; Hey-Hawkins, Evamarie
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 15 p. 4830 - 4837
