2,2-二甲基环丙烯羧酸合成路线 （共 23 条）
参考文献
Russian Chemical Bulletin, , vol. 44, # 1 p. 167 - 171
Izvestiya Akademi Nauk, Seriya Khimicheskaya, , # 1 p. 171 - 175
反应条件
1: Br2 2: aq. Na2CO3 View Scheme
参考文献
Bulletin de la Societe Chimique de France, , p. 1957 - 1963
反应条件
(i) DMF, (ii) aq. NaOH; Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 28, p. 1406 - 1409
参考文献
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, , vol. 45, p. 953
Chem. Zentralbl., , vol. 84, # II p. 2129
反应条件
phosphorus trichoride Behandlung des entstandenen Chlorids mit NH3;
参考文献
Wills, Max T.; Wills, Irene E.; Dollen, Lawrence Von; Butler, Barry L.; Porter, John; Anderson, Arthur G.
Journal of Organic Chemistry, 1980 , vol. 45, # 12 p. 2489 - 2498
反应条件
2: 93 percent / pyridine / 1.5 h / Ambient temperature 3: 83 percent / 3 M NH3 / ethanol / 0.75 h 4: 28 percent / toluene / Heating 5: 1.) NH3 (liq.), Na / 2.) MeOH, 45 deg C, 15 min View Scheme
参考文献
Graham, Donald W.; Ashton, Wallace T.; Barash, Louis; Brown, Jeannette E.; Brown, Ronald D.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 6 p. 1074 - 1090
反应条件
potassium cyanide; sodium hydroxide in pyridine; methanol; dichloromethane; water; ethylene glycol; N,N-dimethyl-formamide
参考文献
Avanir Pharmaceuticals
Patent: US6271390 B1, 2001 ;
反应条件
2: 93 percent / pyridine / 1.5 h / Ambient temperature 3: 83 percent / 3 M NH3 / ethanol / 0.75 h View Scheme
参考文献
Graham, Donald W.; Ashton, Wallace T.; Barash, Louis; Brown, Jeannette E.; Brown, Ronald D.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 6 p. 1074 - 1090
参考文献
Graham, Donald W.; Ashton, Wallace T.; Barash, Louis; Brown, Jeannette E.; Brown, Ronald D.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 6 p. 1074 - 1090
参考文献
Brown,H.C. et al.
Journal of the American Chemical Society, 1977 , vol. 99, # 2 p. 505 - 509
