4-氰基-2-硝基二苯基合成路线 （共 11 条）
反应条件
sodium hydroxide; dihydrogen peroxide in propan-1-ol 6 h; Heating;
参考文献
Ruolene, Yu. I.; Adomenas, P. V.; Adomenene, O. K.; Denis, G. I.
Journal of Organic Chemistry USSR (English Translation), 1984 , vol. 20, p. 1192 - 1195
Zhurnal Organicheskoi Khimii, 1984 , vol. 20, # 6 p. 1310 - 1314
反应条件
quinoline; copper(l) iodide; PdI2; biphenyl-2-yl-di-tert-butyl-phosphane in 1-methyl-pyrrolidin-2-one
T=160°C; 24 h; Inert atmosphere;
参考文献
Goossen, Lukas J.; Zimmermann, Bettina; Knauber, Thomas
Angewandte Chemie - International Edition, 2008 , vol. 47, # 37 p. 7103 - 7106
反应条件
1: ortho-nitrobenzoic acid With cupric(II) carbonate in various solvent(s)
T=120°C; 0.5 h;
2: para-bromobenzonitrile With potassium fluoride; palladium acetylacetonate; iso-propyldiphenylphoshine in various solvent(s)
T=120°C; 24 h; Further stages.;
参考文献
Goossen, Lukas J.; Rodriguez, Nuria; Melzer, Bettina; Linder, Christophe; Deng, Guojun; Levy, Laura M.
Journal of the American Chemical Society, 2007 , vol. 129, # 15 p. 4824 - 4833
反应条件
1: ortho-nitrobenzoic acid With potassium carbonate in various solvent(s)
T=120°C; 0.5 h;
2: para-chloro-benzonitrile With 1,10-phenanthroline; copper(l) iodide in various solvent(s)
T=160°C; 24 h; Further stages.;
参考文献
Goossen, Lukas J.; Rodriguez, Nuria; Melzer, Bettina; Linder, Christophe; Deng, Guojun; Levy, Laura M.
Journal of the American Chemical Society, 2007 , vol. 129, # 15 p. 4824 - 4833
反应条件
sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide
T=150°C; Suzuki-Miyaura cross-coupling reaction; 0.166667 h; microwave irradiation;
参考文献
Appukkuttan, Prasad; Van Der Eycken, Erik; Dehaen, Wim
Synlett, 2005 , # 1 art. no. G33904ST, p. 127 - 133
反应条件
palladium diacetate in 1,4-dioxane
T=20°C; Suzuki-Miyamura cross-coupling; chemoselective reaction;
参考文献
Kuethe, Jeffrey T.; Childers, Karla G.
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 10 p. 1577 - 1586
反应条件
P(t-Bu)2Me*HBF4; palladium diacetate; potassium carbonate; 2,2,2-trimethylacetic acid in 1,3,5-trimethyl-benzene
T=125°C; 16 h; Inert atmosphere; regioselective reaction;
参考文献
Caron, Laurence; Campeau, Louis-Charles; Fagnou, Keith
Organic Letters, 2008 , vol. 10, # 20 p. 4533 - 4536
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in water; N,N-dimethyl-formamide
T=80°C; 5 h; Inert atmosphere;
参考文献
Gao, Hongyin; Xu, Qing-Long; Yousufuddin, Muhammed; Ess, Daniel H.; Kuerti, Laszlo
Angewandte Chemie - International Edition, 2014 , vol. 53, # 10 p. 2701 - 2705
Angew. Chem., 2014 , vol. 53, # 10 p. 2739 - 2743,5
反应条件
1: 63 percent / fuming HNO3; urea
2: 74 percent / aq. NaHCO3 / Pd(Ph3P)4 / dimethylformamide / 0.17 h / 150 °C / microwave irradiation
View Scheme
参考文献
Appukkuttan, Prasad; Van Der Eycken, Erik; Dehaen, Wim
Synlett, 2005 , # 1 art. no. G33904ST, p. 127 - 133
反应条件
nitric acid; acetic anhydride
0.333333 h; Ambient temperature;
参考文献
Ruolene, Yu. I.; Adomenas, P. V.; Adomenene, O. K.; Denis, G. I.
Journal of Organic Chemistry USSR (English Translation), 1984 , vol. 20, p. 1192 - 1195
Zhurnal Organicheskoi Khimii, 1984 , vol. 20, # 6 p. 1310 - 1314
