1: SOCl2 2: 1) ozone 2) dimethyl sulfide / 1) 3 in MeOH at -78 deg C 2) room temperature overnight 3: 57 percent / NaBH4 / ethanol / 3 h 4: 82 percent / NaH / tetrahydrofuran / 24.5 h / Heating 5: 49 percent / 4.5M HCl / H2O / 24 h / Heating View Scheme

1: SOCl2 2: 1) BF3*THF 2) NaOH, 30percent H2O2 / 2) at 55-60 deg C for 90 min 3: 88 percent / triethylamine / CH2Cl2 / 2.5 h / Ambient temperature 4: 95 percent / dimethylformamide / 2 h / 60 °C 5: 73 percent / hydrazine,water / 2-methyl-propan-2-ol / 3.5 h / Heating 6: 78 percent / lithium diisopropyl amid / tetrahydrofuran / 0.75 h 7: 61 percent / 4.5M HCl / H2O / 24 h / Heating View Scheme

1: SOCl2 2: 1) BF3*THF 2) NaOH, 30percent H2O2 / 2) at 55-60 deg C for 90 min 3: 72 percent / NaH / tetrahydrofuran / 20 h / Heating 4: 65 percent / 4.5M HCl / 18 h / Heating View Scheme

1: SOCl2 2: 1) ozone 2) dimethyl sulfide / 1) 3 in MeOH at -78 deg C 2) room temperature overnight 3: 57 percent / NaBH4 / ethanol / 3 h 4: 95 percent / pyridine / 24 h 5: 63 percent / dimethylformamide / 13 h / 60 - 65 °C 6: 72 percent / hydrazine / 2-methyl-propan-2-ol / 3 h / Heating 7: 83.5 percent / diisopropylamine,n-BuLi / tetrahydrofuran / 1 h / -45 °C 8: 68 percent / 4.5M HCl / 30 h / Heating View Scheme

1: SOCl2 2: 1) BF3*THF 2) NaOH, 30percent H2O2 / 2) at 55-60 deg C for 90 min 3: 88 percent / triethylamine / CH2Cl2 / 2.5 h / Ambient temperature 4: 100 percent / LiBr / dimethylformamide 5: 80 percent / Mg / tetrahydrofuran / 48 h / Heating 6: 67 percent / 4.5M HCl / 18 h / Heating View Scheme