4-羰基-1-苯基环己羧酸甲酯合成路线 （共 10 条）
反应条件
1: With acetyl chloride 20 h; Heating / reflux; 2: in tetrahydrofuran; water; acetic acid T=45°C; 2 h;
参考文献
Castro Pineiro, Jose Luis; Dinnell, Kevin; Elliott, Jason Matthew; Hollingworth, Gregory John; Shaw, Duncan Edward; Swain, Christopher John
Patent: US2003/236250 A1, 2003 ;
Location in patent: Page 20 ;
反应条件
methanol; sodium methylate
参考文献
Journal of the American Chemical Society, , vol. 68, p. 828,831
反应条件
1: 55 percent / p-toluenesulfonic acid / CH2Cl2 / 24 h / Heating 2: 96 percent / NaNH2 / dimethylsulfoxide / 1 h / 50 °C 3: 77 percent / KOH / ethane-1,2-diol; H2O / 48 h / Heating 4: 92 percent / acetic acid / 24 h / Heating 5: 1.) NaOH / 1.) EtOH, HMPT, 10 min, 2.) 50 deg C, 2 h View Scheme
参考文献
Archiv der Pharmazie (Weinheim, Germany), , vol. 313, # 6 p. 487 - 498
反应条件
1: 77 percent / KOH / ethane-1,2-diol; H2O / 48 h / Heating 2: 92 percent / acetic acid / 24 h / Heating 3: 1.) NaOH / 1.) EtOH, HMPT, 10 min, 2.) 50 deg C, 2 h View Scheme
参考文献
Archiv der Pharmazie (Weinheim, Germany), , vol. 313, # 6 p. 487 - 498
反应条件
1: 96 percent / NaNH2 / dimethylsulfoxide / 1 h / 50 °C 2: 77 percent / KOH / ethane-1,2-diol; H2O / 48 h / Heating 3: 92 percent / acetic acid / 24 h / Heating 4: 1.) NaOH / 1.) EtOH, HMPT, 10 min, 2.) 50 deg C, 2 h View Scheme
参考文献
Archiv der Pharmazie (Weinheim, Germany), , vol. 313, # 6 p. 487 - 498
反应条件
1: 96 percent / NaNH2 / dimethylsulfoxide / 1 h / 50 °C 2: 77 percent / KOH / ethane-1,2-diol; H2O / 48 h / Heating 3: 92 percent / acetic acid / 24 h / Heating 4: 1.) NaOH / 1.) EtOH, HMPT, 10 min, 2.) 50 deg C, 2 h View Scheme
参考文献
Archiv der Pharmazie (Weinheim, Germany), , vol. 313, # 6 p. 487 - 498
参考文献
Journal of Organic Chemistry, , vol. 16, p. 443,446
反应条件
hydrogenchloride 96 h; Heating;
参考文献
Schneider, Woldemar; Krombholz, Gottfried
Archiv der Pharmazie (Weinheim, Germany), 1980 , vol. 313, # 6 p. 487 - 498
反应条件
1: 92 percent / acetic acid / 24 h / Heating 2: 1.) NaOH / 1.) EtOH, HMPT, 10 min, 2.) 50 deg C, 2 h View Scheme
参考文献
Archiv der Pharmazie (Weinheim, Germany), , vol. 313, # 6 p. 487 - 498
参考文献
Journal of Organic Chemistry, , vol. 16, p. 443,446
