4-氧代-1-苯基环己烷羧酸合成路线 （共 15 条）
反应条件
1: With acetyl chloride 20 h; Heating / reflux; 2: in tetrahydrofuran; water; acetic acid T=45°C; 2 h;
参考文献
Castro Pineiro, Jose Luis; Dinnell, Kevin; Elliott, Jason Matthew; Hollingworth, Gregory John; Shaw, Duncan Edward; Swain, Christopher John
Patent: US2003/236250 A1, 2003 ;
Location in patent: Page 20 ;
反应条件
methanol; sodium methylate
参考文献
Schneider, Woldemar; Krombholz, Gottfried
Archiv der Pharmazie (Weinheim, Germany), 1980 , vol. 313, # 6 p. 487 - 498
参考文献
Rubin; Wishinsky
Journal of Organic Chemistry, 1951 , vol. 16, p. 443,446
反应条件
lithium hydroxide; water in tetrahydrofuran; methanol
72 h; Heating / reflux;
参考文献
Castro Pineiro, Jose Luis; Dinnell, Kevin; Elliott, Jason Matthew; Hollingworth, Gregory John; Shaw, Duncan Edward; Swain, Christopher John
Patent: US2003/236250 A1, 2003 ;
Location in patent: Page 20 ;
反应条件
1: With lithium hydroxide in tetrahydrofuran; methanol; water
72 h; Heating / reflux;
2: With hydrogenchloride; water
pH=1;
参考文献
Pineiro, Jose Luis Castro; Dinnell, Kevin; Elliott, Jason Matthew; Hollingworth, Gregory John; Shaw, Duncan Edward; Swain, Christopher John; Yang, Lihu
Patent: US2003/225059 A1, 2003 ;
Location in patent: Page 21 ;
反应条件
hydrogenchloride; potassium hydroxide; toluene-4-sulfonic acid in ethylene glycol; toluene
参考文献
Pharmacia and Upjohn AB
Patent: US6124354 A1, 2000 ;
反应条件
acetic acid
24 h; Heating;
参考文献
Schneider, Woldemar; Krombholz, Gottfried
Archiv der Pharmazie (Weinheim, Germany), 1980 , vol. 313, # 6 p. 487 - 498
反应条件
1: With sodium hydride in N,N-dimethyl-formamide
T=0 - 20°C;
2: With methanol; lithium hydroxide; water in tetrahydrofuran
Heating;
3: With hydrogenchloride
T=20°C;
参考文献
Elliott, Jason M; Castro, Jose L; Chicchi, Gary G; Cooper, Laura C; Dinnell, Kevin; Hollingworth, Gregory J; Ridgill, Mark P; Rycroft, Wayne; Kurtz, Marc M; Shaw, Duncan E; Swain, Christopher J; Tsao, Kwei-Lan; Yang, Lihu
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 13 p. 1755 - 1758
反应条件
1: 55 percent / p-toluenesulfonic acid / CH2Cl2 / 24 h / Heating
2: 96 percent / NaNH2 / dimethylsulfoxide / 1 h / 50 °C
3: 77 percent / KOH / ethane-1,2-diol; H2O / 48 h / Heating
4: 92 percent / acetic acid / 24 h / Heating
View Scheme
参考文献
Schneider, Woldemar; Krombholz, Gottfried
Archiv der Pharmazie (Weinheim, Germany), 1980 , vol. 313, # 6 p. 487 - 498
反应条件
1: 77 percent / KOH / ethane-1,2-diol; H2O / 48 h / Heating
2: 92 percent / acetic acid / 24 h / Heating
View Scheme
参考文献
Schneider, Woldemar; Krombholz, Gottfried
Archiv der Pharmazie (Weinheim, Germany), 1980 , vol. 313, # 6 p. 487 - 498
