4-氧代-1-苯基环己烷羧酸合成路线 （共 15 条）
反应条件
1: 96 percent / NaNH2 / dimethylsulfoxide / 1 h / 50 °C
2: 77 percent / KOH / ethane-1,2-diol; H2O / 48 h / Heating
3: 92 percent / acetic acid / 24 h / Heating
View Scheme
参考文献
Schneider, Woldemar; Krombholz, Gottfried
Archiv der Pharmazie (Weinheim, Germany), 1980 , vol. 313, # 6 p. 487 - 498
反应条件
1: 96 percent / NaNH2 / dimethylsulfoxide / 1 h / 50 °C
2: 77 percent / KOH / ethane-1,2-diol; H2O / 48 h / Heating
3: 92 percent / acetic acid / 24 h / Heating
View Scheme
参考文献
Schneider, Woldemar; Krombholz, Gottfried
Archiv der Pharmazie (Weinheim, Germany), 1980 , vol. 313, # 6 p. 487 - 498
反应条件
Erhitzen des Reaktionsprodukts unter vermindertem Druck auf 220-240grad;
参考文献
Rubin; Wishinsky
Journal of the American Chemical Society, 1946 , vol. 68, p. 828,831
反应条件
1: With diphenyl phosphoryl azide; triethylamine in toluene
T=90°C; Curtius rearrangement;
2: With hydrogenchloride
Heating;
参考文献
Elliott, Jason M; Castro, Jose L; Chicchi, Gary G; Cooper, Laura C; Dinnell, Kevin; Hollingworth, Gregory J; Ridgill, Mark P; Rycroft, Wayne; Kurtz, Marc M; Shaw, Duncan E; Swain, Christopher J; Tsao, Kwei-Lan; Yang, Lihu
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 13 p. 1755 - 1758
参考文献
Rubin; Wishinsky
Journal of the American Chemical Society, 1946 , vol. 68, p. 828,831
