2,3-二羟基-1,4-苯二羧酸二甲酯合成路线 （共 9 条）
反应条件
1: 85 percent / KI, K2CO3 / acetone / 96 h / Heating 2: 94 percent / 3.3 M aq. NaOH / 1,2-dimethoxy-ethane / 9 h / Heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 113, # 8 p. 2965 - 2977
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 85 °C / Inert atmosphere 2: potassium hydroxide; water / tetrahydrofuran / 20 °C View Scheme
参考文献
WO2012/106534 A2, ;
WO 2012/106534 A2
反应条件
1: bis-methoxymethylenoxy-1,2 benzene With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in diethyl ether
T=0 - 20°C; 0.5 h;
2: carbon dioxide in diethyl ether
1 h;
3: methanol With chloro-trimethyl-silane
Heating / reflux;
参考文献
IRM LLC
Patent: WO2008/73138 A2, 2008 ;
Location in patent: Page/Page column 32 ;
反应条件
chloro-trimethyl-silane
16 h; Heating;
参考文献
Chen; Bednarz; Sundeen; Zhang; Caulfield; Bisacchi
Organic Preparations and Procedures International, 1999 , vol. 31, # 1 p. 106 - 109
反应条件
hydrogenchloride
60 h; Heating;
参考文献
Weitl, Frederick L.; Raymond, Kenneth N.; Durbin, Patricia W.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 2 p. 203 - 206
反应条件
1: 40 percent / NaOH / 48 h / 200 °C / 52505.3 Torr
2: conc. H2SO4 / 8 h / Heating
View Scheme
参考文献
Janssen; Utley; Carre; Simon; Schirmer
Journal of the Chemical Society, Perkin Transactions 2, 2001 , # 9 p. 1573 - 1584
参考文献
v. Euler et al.
Arkiv foer Kemi, 1941 , vol. 14 A, # 10 p. 8,9, 17, 18
反应条件
bubbling air in water
T=20°C; 12 h; Irradiation; Product distribution;
参考文献
Yamada, Sachiko; Hokari, Hajime; Akasaka, Shinji; Iwamura, Michiko
Chemistry Letters, 1999 , # 3 p. 197 - 198
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=0 - 20°C; 4 h;
参考文献
Janssen; Utley; Carre; Simon; Schirmer
Journal of the Chemical Society, Perkin Transactions 2, 2001 , # 9 p. 1573 - 1584
