甲基5-(氨基甲基)噻吩-2-羧酸酯合成路线 （共 5 条）
反应条件
tin(ll) chloride in methanol
T=20°C; 5 h; Inert atmosphere;
参考文献
Casagrande, Manolo; Barteselli, Anna; Basilico, Nicoletta; Parapini, Silvia; Taramelli, Donatella; Sparatore, Anna
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 19 p. 5965 - 5979
反应条件
1: H2SO4 / 6 h / Heating
2: NBS; benzoyl peroxide / CCl4 / 20 h / Heating
3: NaN3 / dimethylformamide / 3 h / 70 °C
4: 2 g / H2; aq. HCl / Pd/C / ethanol / 20 h / 1500.12 Torr
View Scheme
参考文献
Rueckle, Thomas; Biamonte, Marco; Grippi-Vallotton, Tania; Arkinstall, Steve; Cambet, Yves; Camps, Montserrat; Chabert, Christian; Church, Dennis J.; Halazy, Serge; Jiang, Xuliang; Martinou, Isabelle; Nichols, Anthony; Sauer, Wolfgang; Gotteland, Jean-Pierre
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6921 - 6934
反应条件
1: NBS; benzoyl peroxide / CCl4 / 20 h / Heating
2: NaN3 / dimethylformamide / 3 h / 70 °C
3: 2 g / H2; aq. HCl / Pd/C / ethanol / 20 h / 1500.12 Torr
View Scheme
参考文献
Rueckle, Thomas; Biamonte, Marco; Grippi-Vallotton, Tania; Arkinstall, Steve; Cambet, Yves; Camps, Montserrat; Chabert, Christian; Church, Dennis J.; Halazy, Serge; Jiang, Xuliang; Martinou, Isabelle; Nichols, Anthony; Sauer, Wolfgang; Gotteland, Jean-Pierre
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6921 - 6934
反应条件
1: NaN3 / dimethylformamide / 3 h / 70 °C
2: 2 g / H2; aq. HCl / Pd/C / ethanol / 20 h / 1500.12 Torr
View Scheme
参考文献
Rueckle, Thomas; Biamonte, Marco; Grippi-Vallotton, Tania; Arkinstall, Steve; Cambet, Yves; Camps, Montserrat; Chabert, Christian; Church, Dennis J.; Halazy, Serge; Jiang, Xuliang; Martinou, Isabelle; Nichols, Anthony; Sauer, Wolfgang; Gotteland, Jean-Pierre
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6921 - 6934
反应条件
1: 90 percent / DIEA / CH2Cl2 / 2 h / 20 °C
2: aq. LiOH / tetrahydrofuran / 5 h / 60 °C
View Scheme
参考文献
Rueckle, Thomas; Biamonte, Marco; Grippi-Vallotton, Tania; Arkinstall, Steve; Cambet, Yves; Camps, Montserrat; Chabert, Christian; Church, Dennis J.; Halazy, Serge; Jiang, Xuliang; Martinou, Isabelle; Nichols, Anthony; Sauer, Wolfgang; Gotteland, Jean-Pierre
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6921 - 6934
