4-(氯甲基)-3-甲氧基-5-甲基-1,2-恶唑合成路线 （共 8 条）
反应条件
1: 45 percent / sodium ethoxide / ethanol / 4.5 h / Heating 2: 86 percent / HBr, triethylamine / H2O; ethanol / 0.33 h / Heating View Scheme
参考文献
Hansen; Krogsgaard-Larsen
Journal of the Chemical Society. Perkin transactions 1, 1980 , vol. 8, p. 1826 - 1833
反应条件
1: 12 percent / 3 h / 180 °C 2: 46 percent / sodium methoxide / methanol / 3 h / Heating 3: 92 percent / 1 M hydrochloric acid / 4 h / Heating 4: 44 percent / 33percent hydrogen bromide / acetic acid / 24 h / 25 °C View Scheme
参考文献
Krogsgaard-Larsen; Ferkany; Nielsen; Madsen; Ebert; Johansen; Diemer; Bruhn; Beattie; Curtis
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 123 - 130
反应条件
1: 1.) NaH / 1.) EtOH, 10 min, 2.) EtOH, reflux, 24 h 2: 93 percent / 48percent HBr / 5 h / 130 - 140 °C View Scheme
参考文献
Hansen; Krogsgaard-Larsen
Journal of the Chemical Society. Perkin transactions 1, 1980 , vol. 8, p. 1826 - 1833
反应条件
thionyl chloride
0.416667 h; Heating;
参考文献
Hansen; Krogsgaard-Larsen
Journal of the Chemical Society. Perkin transactions 1, 1980 , vol. 8, p. 1826 - 1833
反应条件
1: 67 percent / BH3 / tetrahydrofuran / 16 h / Heating
2: 70 percent / thionyl chloride / benzene / 24 h / Heating
View Scheme
参考文献
Hanson, Robert N.; Mohamed, Fand A.
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 1 p. 345 - 348
反应条件
1: 61 percent / KOH / 96 h / Heating
2: 67 percent / BH3 / tetrahydrofuran / 16 h / Heating
3: 70 percent / thionyl chloride / benzene / 24 h / Heating
View Scheme
参考文献
Hanson, Robert N.; Mohamed, Fand A.
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 1 p. 345 - 348
反应条件
1: 90 percent / aq. KOH / ethanol / 4 h / Ambient temperature
2: 61 percent / KOH / 96 h / Heating
3: 67 percent / BH3 / tetrahydrofuran / 16 h / Heating
4: 70 percent / thionyl chloride / benzene / 24 h / Heating
View Scheme
参考文献
Hanson, Robert N.; Mohamed, Fand A.
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 1 p. 345 - 348
反应条件
1: 75 percent / LiAlH4 / diethyl ether / 6 h / Ambient temperature
2: 80 percent / thionyl chloride / 0.42 h / Heating
View Scheme
参考文献
Hansen; Krogsgaard-Larsen
Journal of the Chemical Society. Perkin transactions 1, 1980 , vol. 8, p. 1826 - 1833
