(乙酰氨基)[(3-甲氧基-5-甲基-4-异恶唑基)甲基]丙二酸二乙酯合成路线 （共 4 条）
反应条件
hydrogen bromide; triethylamine in ethanol; water 0.333333 h; Heating;
参考文献
Hansen; Krogsgaard-Larsen
Journal of the Chemical Society. Perkin transactions 1, 1980 , vol. 8, p. 1826 - 1833
反应条件
hydrogen bromide T=130 - 140°C; 5 h;
参考文献
Hanson, Robert N.; Mohamed, Fand A.
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 1 p. 345 - 348
反应条件
1: 1 M aq. HCl / 8 h / Heating
2: Et3N / H2O; ethanol / pH 6
3: 45 percent / CH3COOH / 1.17 h / Heating
5: 67 percent / 48percent aq. HBr / 0.38 h / 140 °C / Heating
View Scheme
参考文献
Hansen; Lauridsen; Nielsen; Krogsgaard Larsen
Journal of Medicinal Chemistry, 1983 , vol. 26, # 6 p. 901 - 903
反应条件
1: 1 M aq. HCl / 8 h / Heating
2: Et3N / H2O; ethanol / pH 6
3: 45 percent / CH3COOH / 1.17 h / Heating
5: 62 percent / 43percent aq. HBr, CH3COOH / 77 h / 22 °C
View Scheme
参考文献
Hansen; Lauridsen; Nielsen; Krogsgaard Larsen
Journal of Medicinal Chemistry, 1983 , vol. 26, # 6 p. 901 - 903
