4-羟基-2-(三氟甲基)喹啉-3-羧酸乙酯合成路线 （共 6 条）
参考文献
Vertex Pharmaceuticals Incorporated
Patent: US2012/309758 A1, 2012 ;
Location in patent: Page/Page column 63 ;
US 20120309758 A1
参考文献
Roussel Uclaf
Patent: US4299831 A1, 1981 ;
反应条件
sulfuric acid
24 h; Reflux;
参考文献
Isobe, Akira; Takagi, Jun; Katagiri, Toshimasa; Uneyama, Kenji
Organic Letters, 2008 , vol. 10, # 13 p. 2657 - 2659
反应条件
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
1.2: 0 - 20 °C
2.1: 1 h / 210 °C
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参考文献
Vertex Pharmaceuticals Incorporated
Patent: US2012/309758 A1, 2012 ;
US 20120309758 A1
反应条件
1.1: triethylamine; triphenylphosphine; tetrachloromethane / 0.17 h / Cooling with ice
1.2: 3 h / Reflux
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
2.2: 0 - 20 °C
3.1: 1 h / 210 °C
View Scheme
参考文献
Vertex Pharmaceuticals Incorporated
Patent: US2012/309758 A1, 2012 ;
US 20120309758 A1
反应条件
1: NaH / tetrahydrofuran; mineral oil
View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
