1.1: 90 °C 2.1: n-butyllithium / tetrahydrofuran / 1 h / -85 - -75 °C / Industry scale 2.2: 3 h View Scheme
参考文献
GLAXO GROUP LIMITED; Atkinson, Francis Louis; Barker, Michael David; Douault, Clement; Garton, Neil Stuart; Liddle, John; Patel, Vipulkumar Kantibhai; Preston, Alexander George Steven; Wilson, David Matthew
Patent: US2013/40984 A1, 2013 ;
1: dodec-1-ene With PyBH2I in dichloromethane T=20°C; 2 h; 2: With sodium hydroxide; water in dichloromethane T=0 - 20°C; 3: 2,3-dimethylbutane-2,3-diol in dichloromethane; water T=20°C; 15 h;
参考文献
Karatjas, Andrew G.; Vedejs, Edwin
Journal of Organic Chemistry, 2008 , vol. 73, # 23 p. 9508 - 9510