反应条件
1: 1-(tert-butyldimethylsilanyl)-5-fluoro-1H-indole With N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in tetrahydrofuran; cyclohexane T=-78°C; 2 h; 2: With tri-isopropoxy-borane in tetrahydrofuran; cyclohexane T=-78 - -20°C; 3: 2,3-dimethylbutane-2,3-diol in tetrahydrofuran; cyclohexane T=20°C;
参考文献
Safina, Brian S.; Baker, Stewart; Baumgardner, Matt; Blaney, Paul M.; Chan, Bryan K.; Chen, Yung-Hsiang; Cartwright, Matthew W.; Castanedo, Georgette; Chabot, Christine; Cheguillaume, Arnaud J.; Goldsmith, Paul; Goldstein, David M.; Goyal, Bindu; Hancox, Timothy; Handa, Raj K.; Iyer, Pravin S; Kaur, Jasmit; Kondru, Rama; Kenny, Jane R.; Krintel, Sussie L.; Li, Jun; Lesnick, John; Lucas, Matthew C.; Lewis, Cristina; Mukadam, Sophie; Murray, Jeremy; Nadin, Alan J.; Nonomiya, Jim; Padilla, Fernando; Palmer, Wylie S.; Pang, Jodie; Pegg, Neil; Price, Steve; Reif, Karin; Salphati, Laurent; Savy, Pascal A.; Seward, Eileen M.; Shuttleworth, Stephen; Sohal, Sukhjit; Sweeney, Zachary K.; Tay, Suzanne; Tivitmahaisoon, Parcharee; Waszkowycz, Bohdan; Wei, Binqing; Yue, Qin; Zhang, Chenghong; Sutherlin, Daniel P.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 12 p. 5887 - 5900
