3-溴-2-甲基苯甲酸合成路线

参考文献

Curtin, Michael L.; Frey, Robin R.; Heyman, H. Robin; Sarris, Kathy A.; Steinman, Douglas H.; Holmes, James H.; Bousquet, Peter F.; Cunha, George A.; Moskey, Maria D.; Ahmed, Asma A.; Pease, Lori J.; Glaser, Keith B.; Stewart, Kent D.; Davidsen, Steven K.; Michaelides, Michael R.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 17 p. 4505 - 4509

76006-33-23-溴-2-甲基苯甲酸

52780-15-13-溴-2-甲基苯甲腈

参考文献

Zhang, Yong-Kang; Plattner, Jacob J.; Freund, Yvonne R.; Easom, Eric E.; Zhou, Yasheen; Gut, Jiri; Rosenthal, Philip J.; Waterson, David; Gamo, Francisco-Javier; Angulo-Barturen, Inigo; Ge, Min; Li, Zhiya; Li, Lingchao; Jian, Yong; Cui, Han; Wang, Hailong; Yang, Jian
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 2 p. 644 - 651

76006-33-23-溴-2-甲基苯甲酸

21900-41-45-溴-2-甲氧基苄氯

参考文献

Deshpande, Prashant P.; Ellsworth, Bruce A.; Singh, Janak; Denzel, Theodor W.; Lai, Chiajen; Crispino, Gerard; Randazzo, Michael E.; Gougoutas, Jack Z.
Patent: US2004/138439 A1, 2004 ;
Location in patent: Page 16 ;
US 20040138439 A1

76006-33-23-溴-2-甲基苯甲酸+

79669-49-12-甲基-5-溴苯甲酸+

74-88-4甲基碘

99548-54-62-甲基-3-溴苯甲酸甲酯+

79669-50-42-甲基-5-溴苯甲酸甲酯

参考文献

ASTRAZENECA AB
Patent: WO2005/100351 A1, 2005 ;
Location in patent: Page/Page column 13; 16-17 ;
WO 2005/100351 A1

67-56-1甲醇+

76006-33-23-溴-2-甲基苯甲酸+

79669-49-12-甲基-5-溴苯甲酸

99548-54-62-甲基-3-溴苯甲酸甲酯+

79669-50-42-甲基-5-溴苯甲酸甲酯

参考文献

Wyeth
Patent: US2007/203116 A1, 2007 ;
Location in patent: Page/Page column 8; 10 ;
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76006-33-23-溴-2-甲基苯甲酸

955929-54-12-甲基-3-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)苯甲酸甲酯

参考文献

Negoro, Kenji; Ohnuki, Kei; Yonetoku, Yasuhiro; Kuramoto, Kazuyuki; Urano, Yasuharu; Watanabe, Hideyuki
Patent: US2012/35196 A1, 2012 ;

67-56-1甲醇+

76006-33-23-溴-2-甲基苯甲酸

99548-54-62-甲基-3-溴苯甲酸甲酯

参考文献

AMGEN INC.
Patent: WO2007/5668 A2, 2007 ;
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WO 2007/005668 A2

76006-33-23-溴-2-甲基苯甲酸+

74-88-4甲基碘

99548-54-62-甲基-3-溴苯甲酸甲酯

参考文献

Robarge, Michael J.; Chen, Roger Shen-Chu; Muller, George W.; Man, Hon-Wah
Patent: US2003/96841 A1, 2003 ;

76006-33-23-溴-2-甲基苯甲酸+

79669-49-12-甲基-5-溴苯甲酸+

74-88-4甲基碘

99548-54-62-甲基-3-溴苯甲酸甲酯+

79669-50-42-甲基-5-溴苯甲酸甲酯

参考文献

ASTRAZENECA AB
Patent: WO2005/100351 A1, 2005 ;
Location in patent: Page/Page column 13; 16-17 ;
WO 2005/100351 A1

76006-33-23-溴-2-甲基苯甲酸

99548-54-62-甲基-3-溴苯甲酸甲酯

参考文献

Dainippon Sumitomo Pharma Co., Ltd.; HORIUCHI, Yoshihiro; FUJIWARA, Hiroaki; SUDA, Hitoshi; SASAKI, Izumi; IWATA, Mitsutaka; SAWAMURA, Kiyoto
Patent: EP2612848 A1, 2013 ;