(R)-5-(2-氨基乙基)-1-(6,8-二氟苯并二氢吡喃-3-基)-1,3-二氢咪唑-2-硫酮合成路线 （共 14 条）
反应条件
sodium hydroxide in dichloromethane; water; isopropyl alcohol
T=35 - 38°C; 0.166667 - 0.25 h;
参考文献
PORTELA and CA., S.A.
Patent: WO2008/94056 A1, 2008 ;
Location in patent: Page/Page column 9 ;
反应条件
sodium tetrahydroborate in dichloromethane; water; isopropyl alcohol
T=20 - 25°C; 16 h;
参考文献
Beliaev, Alexandre; Wahnon, Jorge; Russo, Domenico
Organic Process Research and Development, 2012 , vol. 16, # 4 p. 704 - 709
反应条件
1: sulfuric acid / acetic acid / 1 h / 100 °C
2: sodium hypochlorite; sodium hydroxide / methanol / 24 h / 25 °C
3: hydrogen / methanol / 20 h / 80 °C / 22502.3 Torr
4: water; potassium hydroxide / methanol / 24 h / Reflux
5: ethanol; water / 1 h / 20 °C
6: acetic acid / 2 - 4 h / 100 °C
7: sodium tetrahydroborate / dichloromethane; water; isopropyl alcohol / 16 h / 20 - 25 °C
View Scheme
参考文献
Beliaev, Alexandre; Wahnon, Jorge; Russo, Domenico
Organic Process Research and Development, 2012 , vol. 16, # 4 p. 704 - 709
反应条件
1: sodium hypochlorite; sodium hydroxide / methanol / 24 h / 25 °C
2: hydrogen / methanol / 20 h / 80 °C / 22502.3 Torr
3: water; potassium hydroxide / methanol / 24 h / Reflux
4: ethanol; water / 1 h / 20 °C
5: acetic acid / 2 - 4 h / 100 °C
6: sodium tetrahydroborate / dichloromethane; water; isopropyl alcohol / 16 h / 20 - 25 °C
View Scheme
参考文献
Beliaev, Alexandre; Wahnon, Jorge; Russo, Domenico
Organic Process Research and Development, 2012 , vol. 16, # 4 p. 704 - 709
反应条件
1: hydrogen / methanol / 20 h / 80 °C / 22502.3 Torr
2: water; potassium hydroxide / methanol / 24 h / Reflux
3: ethanol; water / 1 h / 20 °C
4: acetic acid / 2 - 4 h / 100 °C
5: sodium tetrahydroborate / dichloromethane; water; isopropyl alcohol / 16 h / 20 - 25 °C
View Scheme
参考文献
Beliaev, Alexandre; Wahnon, Jorge; Russo, Domenico
Organic Process Research and Development, 2012 , vol. 16, # 4 p. 704 - 709
反应条件
1: water; potassium hydroxide / methanol / 24 h / Reflux
2: ethanol; water / 1 h / 20 °C
3: acetic acid / 2 - 4 h / 100 °C
4: sodium tetrahydroborate / dichloromethane; water; isopropyl alcohol / 16 h / 20 - 25 °C
View Scheme
参考文献
Beliaev, Alexandre; Wahnon, Jorge; Russo, Domenico
Organic Process Research and Development, 2012 , vol. 16, # 4 p. 704 - 709
反应条件
1: sodium hydroxide / water / 1 h / 0 - 5 °C
2: phosphorus pentachloride / dichloromethane / 1 h / 0 - 5 °C
3: AlCl3, aluminium chloride / dichloromethane / 4 h / 3 - 8 °C
4: Pearlman's catalist; sulfuric acid; hydrogen; trifluoroacetic acid / 24 h / 20 °C / 5171.62 Torr
5: water; potassium hydroxide / methanol / 24 h / Reflux
6: ethanol; water / 1 h / 20 °C
7: acetic acid / 2 - 4 h / 100 °C
8: sodium tetrahydroborate / dichloromethane; water; isopropyl alcohol / 16 h / 20 - 25 °C
View Scheme
参考文献
Beliaev, Alexandre; Wahnon, Jorge; Russo, Domenico
Organic Process Research and Development, 2012 , vol. 16, # 4 p. 704 - 709
反应条件
1: AlCl3, aluminium chloride / dichloromethane / 4 h / 3 - 8 °C
2: Pearlman's catalist; sulfuric acid; hydrogen; trifluoroacetic acid / 24 h / 20 °C / 5171.62 Torr
3: water; potassium hydroxide / methanol / 24 h / Reflux
4: ethanol; water / 1 h / 20 °C
5: acetic acid / 2 - 4 h / 100 °C
6: sodium tetrahydroborate / dichloromethane; water; isopropyl alcohol / 16 h / 20 - 25 °C
View Scheme
参考文献
Beliaev, Alexandre; Wahnon, Jorge; Russo, Domenico
Organic Process Research and Development, 2012 , vol. 16, # 4 p. 704 - 709
反应条件
1: phosphorus pentachloride / dichloromethane / 1 h / 0 - 5 °C
2: AlCl3, aluminium chloride / dichloromethane / 4 h / 3 - 8 °C
3: Pearlman's catalist; sulfuric acid; hydrogen; trifluoroacetic acid / 24 h / 20 °C / 5171.62 Torr
4: water; potassium hydroxide / methanol / 24 h / Reflux
5: ethanol; water / 1 h / 20 °C
6: acetic acid / 2 - 4 h / 100 °C
7: sodium tetrahydroborate / dichloromethane; water; isopropyl alcohol / 16 h / 20 - 25 °C
View Scheme
参考文献
Beliaev, Alexandre; Wahnon, Jorge; Russo, Domenico
Organic Process Research and Development, 2012 , vol. 16, # 4 p. 704 - 709
反应条件
1: acetic acid / 2 - 4 h / 100 °C
2: sodium tetrahydroborate / dichloromethane; water; isopropyl alcohol / 16 h / 20 - 25 °C
View Scheme
参考文献
Beliaev, Alexandre; Wahnon, Jorge; Russo, Domenico
Organic Process Research and Development, 2012 , vol. 16, # 4 p. 704 - 709
