N-(6-氯-9h-嘌呤-2-基)乙酰胺合成路线 （共 2 条）
反应条件
1: 1.) Me3SiCl, Et3N; 2.) Hg(CN)2 / 1.) PhH, 40 h; 2.) PhH, reflux. 4 h 2: 67 percent / 2-mercaptoethanol (HSCH2CH2OH), 1M NaOMe / methanol / 3 h / Heating View Scheme
参考文献
Chu; Matulic-Adamic; Huang; Chou; Burchenal; Fox; Watanabe
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 2 p. 336 - 339
反应条件
1: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 18 h / 21 °C / Inert atmosphere
2: 2-hydroxyethanethiol; sodium hydroxide / water / 1.5 h / Inert atmosphere; Reflux; Large scale reaction
View Scheme
参考文献
Brodszki, Martin; Baeckstroem, Birthe; Malmgren, Hakan; Wennerberg, Johan; Larsson, Torbjoern; Pelcman, Mikael; Waehling, Horst; Wallberg, Hans; Horvath, Karol
Organic Process Research and Development, 2011 , vol. 15, # 5 p. 1027 - 1032
