2-巯基-5-(三氟甲基)吡啶合成路线 （共 5 条）
反应条件
1: With thiourea in ethanol T=20°C; 2 h; Heating / reflux; 2: With potassium hydroxide; water in ethanol T=20°C; 2 h; Heating / reflux; 3: With sodium hydroxide; acetic acid in ethanol; dichloromethane
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: WO2006/109729 A1, 2006 ;
Location in patent: Page/Page column 87 ;
反应条件
1: 54.5 percent / antimony trifluoride / 0.17 h / Heating 2: 1) thiourea, 2) KOH, water / 1) ethanol, reflux, 3h, 2) ethanol, reflux, 1h View Scheme
参考文献
Heterocycles, , vol. 22, # 1 p. 117 - 124
反应条件
HOF* CH3CN in dichloromethane T=0°C;
参考文献
Shefer, Neta; Carmeli, Mira; Rozen, Shlomo
Tetrahedron Letters, 2007 , vol. 48, # 46 p. 8178 - 8181
反应条件
hydrogenchloride; chlorine in water T=0°C; 1.5 h;
参考文献
Latli, Bachir; Hrapchak, Matt; Easter, John A.; Stolle, Wayne T.; Grozinger, Karl; Krishnamurthy, Dhileepkumar; Senanayake, Chris H.
Journal of Labelled Compounds and Radiopharmaceuticals, 2008 , vol. 51, # 8 p. 314 - 320
反应条件
1: With chlorine in water; acetic acid T=0°C; 0.75 - 1 h; 2: With ammonium hydroxide in water; acetic acid T=0°C; 0.166667 h;
参考文献
Konradi, Andrei W.; Probst, Gary; Aubele, Danielle L.; Garofalo, Albert W.; Hom, Roy; Neitzel, Martin L.; Semko, Christopher M.; Truong, Anh P.
Patent: US2008/21056 A1, 2008 ;
Location in patent: Page/Page column 93 ;
US 20080021056 A1
