N,N-二乙基-2-溴苯甲酰胺合成路线 （共 19 条）
反应条件
1: 88 percent / NaOtBu / Pd(OAc)2; rac-BINAP / toluene 2: 97 percent / NaH / dimethylformamide 3: 86 percent / LDA; TMEDA; n-BuLi / tetrahydrofuran; hexane / 4 h / -20 °C 4: 75 percent / TMSCl; NaI / acetonitrile 5: 80 percent View Scheme
参考文献
Lohse, Olivier; Beutler, Ulrich; Fuenfschilling, Peter; Furet, Pascal; France, Julien; Kaufmann, Daniel; Penn, Gerhard; Zaugg, Werner
Tetrahedron Letters, 2001 , vol. 42, # 3 p. 385 - 389
反应条件
1: 88 percent / NaOtBu / Pd(OAc)2; rac-BINAP / toluene 2: 97 percent / NaH / dimethylformamide 3: 86 percent / LDA; TMEDA; n-BuLi / tetrahydrofuran; hexane / 4 h / -20 °C View Scheme
参考文献
Lohse, Olivier; Beutler, Ulrich; Fuenfschilling, Peter; Furet, Pascal; France, Julien; Kaufmann, Daniel; Penn, Gerhard; Zaugg, Werner
Tetrahedron Letters, 2001 , vol. 42, # 3 p. 385 - 389
反应条件
CuPF6(MeCN)2; caesium carbonate in xylene Heatingother reagents; Product distribution;
参考文献
Kalinin, Alexey V.; Bower, Justin F.; Riebel, Peter; Snieckus, Victor
Journal of Organic Chemistry, 1999 , vol. 64, # 9 p. 2986 - 2987
反应条件
1: 88 percent / NaOtBu / Pd(OAc)2; rac-BINAP / toluene 2: 85 percent / NaH / dimethylformamide 3: 72 percent / LDA; TMEDA; n-BuLi / tetrahydrofuran; hexane / 2 h / -20 °C 4: p-TsOH / methanol 5: t-BuOK / dimethylsulfoxide View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 3 p. 385 - 389
反应条件
1: 88 percent / NaOtBu / Pd(OAc)2; rac-BINAP / toluene 2: 97 percent / NaH / dimethylformamide 3: 86 percent / LDA; TMEDA; n-BuLi / tetrahydrofuran; hexane / 4 h / -20 °C 4: 75 percent / TMSCl; NaI / acetonitrile View Scheme
参考文献
Lohse, Olivier; Beutler, Ulrich; Fuenfschilling, Peter; Furet, Pascal; France, Julien; Kaufmann, Daniel; Penn, Gerhard; Zaugg, Werner
Tetrahedron Letters, 2001 , vol. 42, # 3 p. 385 - 389
反应条件
1: 1.) n-BuLi / 1.) ether, -78 deg C, 30 min, 2.) ether, from -78 deg C to RT
2: 635 mg / NaBH4 / diethyl ether / 3 h / Ambient temperature
View Scheme
参考文献
Chen, Chin-Wen; Beak, Peter
Journal of Organic Chemistry, 1986 , vol. 51, # 17 p. 3325 - 3334
反应条件
1: N,N-diethyl-o-bromobenzamide; lithium dibutyl(isopropyl)magnesate in tetrahydrofuran; hexane
T=-78°C; 1 h;
2: allyl bromide With CuCN*2LiCl in tetrahydrofuran; hexane
T=-78°C; Further stages.;
参考文献
Inoue; Kitagawa; Shinokubo; Oshima
Journal of Organic Chemistry, 2001 , vol. 66, # 12 p. 4333 - 4339
反应条件
sodium tetrahydroborate; titanium tetrachloride in ethylene glycol dimethyl ether
14 h; Ambient temperature;
参考文献
Kano, Shinzo; Tanaka, Yasuyuki; Sugino, Eiichi; Hibino, Sstoshi
Synthesis, 1980 , # 9 p. 695 - 697
反应条件
1: 81 percent / t-BuONa / Pd2(dba)3, BINAP / toluene / 90 - 100 °C
2: 84 percent
3: 84 percent / LDA / tetrahydrofuran
View Scheme
参考文献
MacNeil, Stephen L.; Gray, Matthew; Briggs, Laura E.; Li, Jim J.; Snieckus
Synlett, 1998 , # 4 p. 419 - 421
