2-溴-3-甲氧基-6-硝基吡啶合成路线 （共 14 条）
反应条件
sulfuric acid; nitric acid T=2 - 55°C;
参考文献
Thompson, Andrew M.; Blaser, Adrian; Anderson, Robert F.; Shinde, Sujata S.; Franzblau, Scott G.; Ma, Zhenkun; Denny, William A.; Palmer, Brian D.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 3 p. 637 - 645
反应条件
nitric acid in water
参考文献
US5929094 A1, ;
US 5929094 A
反应条件
1: 1.) NaOCH3 / 1.) MeOH, DMF; 2.) DMF, RT, 1.5 h 2: 80 percent / fuming HNO3, conc. H2SO4 / 1 h / 60 °C View Scheme
参考文献
Tetrahedron, , vol. 42, # 5 p. 1475 - 1485
反应条件
1: 35 percent / Br2, 10percent aq. NaOH / 24 h 2: 1.) NaOCH3 / 1.) MeOH, DMF; 2.) DMF, RT, 1.5 h 3: 80 percent / fuming HNO3, conc. H2SO4 / 1 h / 60 °C View Scheme
参考文献
Tetrahedron, , vol. 42, # 5 p. 1475 - 1485
反应条件
in methanol; dimethyl sulfoxide T=20 - 35°C; 49.5 h;
参考文献
BIOLIPOX AB
Patent: WO2007/51981 A1, 2007 ;
Location in patent: Page/Page column 56 ;
反应条件
in dimethyl sulfoxide T=20 - 35°C; 49.5 h;
参考文献
BIOLIPOX AB
Patent: WO2007/51982 A1, 2007 ;
Location in patent: Page/Page column 48 ;
反应条件
sodium in dimethyl sulfoxide T=30°C; 2 h;
参考文献
Clark, Gary J.; Deady, Leslie W.
Australian Journal of Chemistry, 1981 , vol. 34, # 4 p. 927 - 932
反应条件
ammonium hydroxide in dichloromethane; water
参考文献
Merck and Co., Inc.
Patent: US5929094 A1, 1999 ;
US 5929094 A
反应条件
hydrogen; platinum(IV) oxide in ethanol P=760 Torr;
参考文献
Clark, Gary J.; Deady, Leslie W.
Australian Journal of Chemistry, 1981 , vol. 34, # 4 p. 927 - 932
反应条件
hydrazine; palladium 10 on activated carbon in ethanol 0.75 h; Heating / reflux;
参考文献
BIOLIPOX AB
Patent: WO2007/51982 A1, 2007 ;
Location in patent: Page/Page column 49 ;
