2-溴-3-甲氧基-6-硝基吡啶合成路线 （共 14 条）
反应条件
hydrazine hydrate; palladium monocarbide in ethanol; water
参考文献
Nihon Medi-Physics Co., Ltd.
Patent: EP2216052 A1, 2010 ;
反应条件
1.1: 95 percent / N2H4*H2O / 5 percent Pd/C / ethanol / 1.5 h / Heating 2.1: Br2 / aq. HBr / cooling 2.2: 67 percent / aq. NaNO2 / 0.5 h / cooling View Scheme
参考文献
Reimann; Erdle
Pharmazie, 2000 , vol. 55, # 12 p. 907 - 912
反应条件
1.1: 95 percent / N2H4*H2O / 5 percent Pd/C / ethanol / 1.5 h / Heating 2.1: Br2 / aq. HBr / cooling 2.2: 67 percent / aq. NaNO2 / 0.5 h / cooling 3.1: BuLi / tetrahydrofuran; hexane / -105 - -100 °C 3.2: tetrahydrofuran; hexane / -100 °C View Scheme
参考文献
Reimann; Erdle
Pharmazie, 2000 , vol. 55, # 12 p. 907 - 912
反应条件
1: 59 percent / H2, NaOH / 10percent Pd/C / ethanol
2: 59 percent / xylene / 24 h / Heating
3: 30percent HBr, AcOH / 120 h / 100 °C
View Scheme
参考文献
Lombardino, Joseph G.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 39 - 42
