n-butyllithium; ethanethiol in N,N,N',N',N'',N''-hexamethylphosphoric triamide T=0 - 70°C; 2 h; Inert atmosphere;

ethanethiol; tin(ll) chloride in acetonitrile T=20°C;

1.1: ethanethiol; n-butyllithium / N,N,N',N',N'',N''-hexamethylphosphoric triamide / 2 h / 0 - 70 °C / |Inert atmosphere 2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C 2.2: 2 h / 0 - 20 °C 3.1: ethanethiol; n-butyllithium / N,N,N',N',N'',N''-hexamethylphosphoric triamide / 2 h / 0 - 70 °C / |Inert atmosphere View Scheme

1.1: AlCl3, aluminium chloride / dichloromethane / 24 h / 0 °C / |Reflux 2.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C 2.2: 0.5 h / |Reflux 3.1: sodium hydride / tetrahydrofuran / 1.67 h / 0 °C / |Reflux 4.1: potassium carbonate / acetone / 0.5 h 4.2: 24 h / |Reflux 5.1: sulfuric acid / acetic acid / 0.5 h / 20 °C 6.1: methanol; sodium tetrahydroborate / 0.5 h 7.1: sulfuric acid / 3 h / |Reflux 8.1: ethanethiol; n-butyllithium / N,N,N',N',N'',N''-hexamethylphosphoric triamide / 2 h / 0 - 70 °C / |Inert atmosphere 9.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C 9.2: 2 h / 0 - 20 °C 10.1: ethanethiol; n-butyllithium / N,N,N',N',N'',N''-hexamethylphosphoric triamide / 2 h / 0 - 70 °C / |Inert atmosphere View Scheme

1.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C 1.2: 0.5 h / |Reflux 2.1: sodium hydride / tetrahydrofuran / 1.67 h / 0 °C / |Reflux 3.1: potassium carbonate / acetone / 0.5 h 3.2: 24 h / |Reflux 4.1: sulfuric acid / acetic acid / 0.5 h / 20 °C 5.1: methanol; sodium tetrahydroborate / 0.5 h 6.1: sulfuric acid / 3 h / |Reflux 7.1: ethanethiol; n-butyllithium / N,N,N',N',N'',N''-hexamethylphosphoric triamide / 2 h / 0 - 70 °C / |Inert atmosphere 8.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C 8.2: 2 h / 0 - 20 °C 9.1: ethanethiol; n-butyllithium / N,N,N',N',N'',N''-hexamethylphosphoric triamide / 2 h / 0 - 70 °C / |Inert atmosphere 10.1: ethanethiol; tin(ll) chloride / acetonitrile / 20 °C View Scheme

1.1: dichloromethane / 0.17 h / 0 °C 1.2: 2 h 2.1: AlCl3, aluminium chloride / dichloromethane / 24 h / 0 °C / |Reflux 3.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C 3.2: 0.5 h / |Reflux 4.1: sodium hydride / tetrahydrofuran / 1.67 h / 0 °C / |Reflux 5.1: potassium carbonate / acetone / 0.5 h 5.2: 24 h / |Reflux 6.1: sulfuric acid / acetic acid / 0.5 h / 20 °C 7.1: methanol; sodium tetrahydroborate / 0.5 h 8.1: sulfuric acid / 3 h / |Reflux 9.1: ethanethiol; n-butyllithium / N,N,N',N',N'',N''-hexamethylphosphoric triamide / 2 h / 0 - 70 °C / |Inert atmosphere 10.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C 10.2: 2 h / 0 - 20 °C 11.1: ethanethiol; n-butyllithium / N,N,N',N',N'',N''-hexamethylphosphoric triamide / 2 h / 0 - 70 °C / |Inert atmosphere View Scheme

1.1: sodium hydride / tetrahydrofuran / 1.67 h / 0 °C / |Reflux 2.1: potassium carbonate / acetone / 0.5 h 2.2: 24 h / |Reflux 3.1: sulfuric acid / acetic acid / 0.5 h / 20 °C 4.1: methanol; sodium tetrahydroborate / 0.5 h 5.1: sulfuric acid / 3 h / |Reflux 6.1: ethanethiol; n-butyllithium / N,N,N',N',N'',N''-hexamethylphosphoric triamide / 2 h / 0 - 70 °C / |Inert atmosphere 7.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C 7.2: 2 h / 0 - 20 °C 8.1: ethanethiol; n-butyllithium / N,N,N',N',N'',N''-hexamethylphosphoric triamide / 2 h / 0 - 70 °C / |Inert atmosphere View Scheme

1.1: sulfuric acid / acetic acid / 0.5 h / 20 °C 2.1: methanol; sodium tetrahydroborate / 0.5 h 3.1: sulfuric acid / 3 h / |Reflux 4.1: ethanethiol; n-butyllithium / N,N,N',N',N'',N''-hexamethylphosphoric triamide / 2 h / 0 - 70 °C / |Inert atmosphere 5.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C 5.2: 2 h / 0 - 20 °C 6.1: ethanethiol; n-butyllithium / N,N,N',N',N'',N''-hexamethylphosphoric triamide / 2 h / 0 - 70 °C / |Inert atmosphere View Scheme

1.1: methanol; sodium tetrahydroborate / 0.5 h 2.1: sulfuric acid / 3 h / |Reflux 3.1: ethanethiol; n-butyllithium / N,N,N',N',N'',N''-hexamethylphosphoric triamide / 2 h / 0 - 70 °C / |Inert atmosphere 4.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C 4.2: 2 h / 0 - 20 °C 5.1: ethanethiol; n-butyllithium / N,N,N',N',N'',N''-hexamethylphosphoric triamide / 2 h / 0 - 70 °C / |Inert atmosphere View Scheme

1.1: sulfuric acid / 3 h / |Reflux 2.1: ethanethiol; n-butyllithium / N,N,N',N',N'',N''-hexamethylphosphoric triamide / 2 h / 0 - 70 °C / |Inert atmosphere 3.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C 3.2: 2 h / 0 - 20 °C 4.1: ethanethiol; n-butyllithium / N,N,N',N',N'',N''-hexamethylphosphoric triamide / 2 h / 0 - 70 °C / |Inert atmosphere View Scheme