7-氟喹唑啉-2,4(1H,3H)-二酮合成路线 （共 5 条）
反应条件
1: With cyanic acid sodium salt; acetic acid in water T=35°C; 0.5 h; 2: With sodium hydroxide in water 3: With hydrogenchloride; water T=0°C; pH=4;
参考文献
Caprathe, Bradley William; Glase, Shelly Ann; Konstantinou, Zissis; Schelkun, Robert Michael; Sheehan, Susan M.; Thomas, Anthony Jerome; Yuen, Po-Wai
Patent: US2005/96327 A1, 2005 ;
Location in patent: Page/Page column 28 ;
US 20050096327 A1
反应条件
1: With acetic acid in water T=20°C; 5 h; 2: With sodium hydroxide in water 1 h; 3: With acetic acid in water pH=5 - 6;
参考文献
Impact Therapeutics, Inc.; Cai, Sui Xiong; Tian, Ye Edward; Dong, Haijun; Xu, Qingbing; Wu, Lizhen; Liu, Lijun; Jiang, Yangzhen; Bao, Qingli; Wang, Guoxiang; Yin, Feng; Gu, Chengyun; Hu, Xiuhua; Wang, Xiaozhu; Kang, Sishun; Chen, Shengzhi
Patent: US2014/23642 A1, 2014 ;
Location in patent: Paragraph 0411 ;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2005/49033 A1, 2005 ;
Location in patent: Page/Page column 112 ;
WO 2005/049033 A1
反应条件
trichlorophosphate 72 h; Heating / reflux;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2005/49033 A1, 2005 ;
Location in patent: Page/Page column 113 ;
WO 2005/049033 A1
反应条件
sulfuric acid; potassium nitrate T=0°C; 1 h;
参考文献
WO2008/20711 A1, ;
Page/Page column 26; 70 ;
WO 2008/020711 A1
