3-氟-4-羟基苯硼酸频那醇酯合成路线 (共 3 条)
反应条件
dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; triethylamine; tris-(dibenzylideneacetone)dipalladium(0) in toluene
T=80°C; 5 h;
参考文献
INFINITY DISCOVERY, INC.
Patent: WO2008/63300 A2, 2008 ;
Location in patent: Page/Page column 198 ;
WO 2008/063300 A2
反应条件
potassium acetate; 1,1'-bis-(diphenylphosphino)ferrocene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in 1,4-dioxane
T=85°C; 17 h; Inert atmosphere; Conversion of starting material;
参考文献
AstraZeneca AB
Patent: US2010/324068 A1, 2010 ;
Location in patent: Page/Page column 30 ;
反应条件
1: 3-fluoro-4-hydroxy-bromobenzene With tert.-butyl lithium in diethyl ether; pentane
T=-78°C; 0.5 h;
2: 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in diethyl ether; pentane
T=-78 - 20°C; Further stages.;
参考文献
Ishikawa, Shunpei; Manabe, Kei
Chemical Communications, 2006 , # 24 p. 2589 - 2591