4-异硫代氰酰基吡啶(9ci)合成路线 （共 5 条）
反应条件
in N,N-dimethyl-formamide 0.5 h; Ambient temperature;
参考文献
Blumenkopf; Harrington; Koble; Bankston; Morrison Jr.; Bigham; Styles; Spector
Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2306 - 2314
反应条件
sodium hydrogencarbonate in chloroform; water
T=0°C; 1 h;
参考文献
Yamada; Yura; Morimoto; Harada; Honma; Kinoshita; Sugiura
Journal of Medicinal Chemistry, 1996 , vol. 39, # 2 p. 596 - 604
反应条件
1: 4-amino-pyridine With sodium hydride in tetrahydrofuran
1 h; Cooling with ice bath;
2: DPTC in tetrahydrofuran
T=20°C;
参考文献
Topotarget A/S; CHRISTENSEN, Mette Knak; BJOeRKLING, Fredrik
Patent: WO2010/142735 A1, 2010 ;
Location in patent: Page/Page column 34; 78 ;
WO 2010/142735 A1
反应条件
triethylamine; dicyclohexyl-carbodiimide in ethyl acetate
T=0°C; Yield given;
参考文献
Hansen, E. T.; Petersen, H. J.
Synthetic Communications, 1984 , vol. 14, # 6 p. 537 - 546
参考文献
Barnikow, Guenter; Lehner, Juergen
Zeitschrift fuer Chemie (Stuttgart, Germany), 1990 , vol. 30, # 10 p. 365
