4-(2-氧代乙基)苯甲腈合成路线 （共 9 条）
反应条件
sodium tetrahydroborate in ethanol; dichloromethane T=20°C; 1 h;
参考文献
Chernyak, Natalia; Buchwald, Stephen L.
Journal of the American Chemical Society, 2012 , vol. 134, # 43 p. 18147 - 18147,1
反应条件
1: (methoxymethyl)-triphenylphosphonium chloride With potassium tert-butylate in tetrahydrofuran
T=-20 - -15°C; 1.5 h;
2: [4-cyanophenyl]methanone in tetrahydrofuran
T=-20 - 20°C; 1.66667 h;
参考文献
MOCHIDA PHARMACEUTICAL CO., LTD.
Patent: EP1568688 A1, 2005 ;
Location in patent: Page/Page column 28-29 ;
反应条件
1: With sodium ethanolate
Darzens Condensation;
2: With hydrogenchloride; water in toluene
参考文献
UNIVERSITEIT ANTWERPEN
Patent: WO2007/45496 A1, 2007 ;
Location in patent: Page/Page column 68-70; 75 ;
WO 2007/045496 A1
反应条件
Dess-Martin periodane in dichloromethane
T=20°C; 1 h;
参考文献
MERCK SHARP and DOHME CORP.; TANG, Haifeng; PIO, Barbara; TEUMELSAN, Nardos; PASTERNAK, Alexander; DEJESUS, Reynalda
Patent: WO2013/62892 A1, 2013 ;
Location in patent: Page/Page column 57 ;
反应条件
1: (methoxymethyl)-triphenylphosphonium chloride With potassium tert-butylate in tetrahydrofuran
T=-20 - 0°C; 1.5 h;
2: [4-cyanophenyl]methanone in tetrahydrofuran
T=-20 - 20°C; 1.66667 h;
3: With hydrogenchloride in water; acetone
1.33333 h; Heating / reflux;
参考文献
MOCHIDA PHARMACEUTICAL CO., LTD.
Patent: EP1391452 A1, 2004 ;
Location in patent: Page 22 ;
反应条件
1: p-aminobenzonitrile With hydrogenchloride in water; acetone
2: With sodium nitrite in water; acetone
0.05 h; Sonication;
3: ethyl vinyl ether Further stages;
参考文献
Chernyak, Natalia; Buchwald, Stephen L.
Journal of the American Chemical Society, 2012 , vol. 134, # 30 p. 12466 - 12469
反应条件
sulfuric acid in chloroform
T=20°C; 2 h;
参考文献
Dai, Liyan; Yu, Jie; Chen, Yingqi; Yu, Shichao
Synthetic Communications, 2011 , vol. 41, # 20 p. 3078 - 3084
反应条件
1: N,N-dimethyl-formamide / 19 h / 140 °C
2: sulfuric acid / chloroform / 2 h / 20 °C
View Scheme
参考文献
Dai, Liyan; Yu, Jie; Chen, Yingqi; Yu, Shichao
Synthetic Communications, 2011 , vol. 41, # 20 p. 3078 - 3084
反应条件
sulfuric acid; sodium nitrite
1.) H2O, 0-3 deg C, 2.) DMSO, 5 deg C, 30 min; Yield given. Multistep reaction;
参考文献
Minisci, Francesco; Coppa, Fausta; Fontana, Francesca; Pianese, Giuseppe; Zhao, Lihua
Journal of Organic Chemistry, 1992 , vol. 57, # 14 p. 3929 - 3933
