2-硝基-5-(甲氧羰基)苯甲酸合成路线 （共 8 条）
反应条件
sulfuric acid in methanol 4 h; Reflux;
参考文献
NEUROTUNE AG; AHMED, Shaheen; HETTWER, Stefan; VRIJBLOED, Jan Willem; FARINA, Carlo; ALLGEIER, Hans
Patent: WO2012/59442 A2, 2012 ;
Location in patent: Page/Page column 38-39; 83 ;
WO 2012/059442 A2
反应条件
sodium chlorite; sodium dihydrogenphosphate; dihydrogen peroxide in water; acetonitrile T=10°C; 2.25 h;
参考文献
WO2004/52839 A1, ;
Page 67 ;
WO 2004/052839 A1
反应条件
1: permanganate 2: 100 °C / im Rohr View Scheme
参考文献
Monatshefte fuer Chemie, , vol. 41, p. 155
参考文献
Monatshefte fuer Chemie, , vol. 41, p. 155
反应条件
1.1: SOCl2 / dimethylformamide / 3 h / Heating 2.1: NaN3 / acetone; H2O / 0.25 h / 20 °C 3.1: 2-(trimethylsilyl)ethanol / xylene / 16 h / Heating 3.2: TBAF / tetrahydrofuran / 0.5 h / 20 °C View Scheme
参考文献
Hay, Michael P.; Sykes, Bridget M.; Denny, William A.; O'Connor, Charmian J.
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 19 p. 2759 - 2770
反应条件
hydrogenchloride; tin
参考文献
NEUROTUNE AG; AHMED, Shaheen; HETTWER, Stefan; VRIJBLOED, Jan Willem; FARINA, Carlo; ALLGEIER, Hans
Patent: WO2012/59442 A2, 2012 ;
Location in patent: Page/Page column 96 ;
WO 2012/059442 A2
反应条件
1: SOCl2 / dimethylformamide / 0.75 h / Heating 2: benzene; diethyl ether / 2 h / 20 °C 3: Ag2O / 0.5 h / Heating View Scheme
参考文献
Atwell, Graham J.; Sykes, Bridget M.; O'Connor, Charmian J.; Denny, William A.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 3 p. 371 - 380
反应条件
1.1: SOCl2 / dimethylformamide / 3 h / Heating 2.1: NaN3 / acetone; H2O / 0.25 h / 20 °C 3.1: 2-(trimethylsilyl)ethanol / xylene / 16 h / Heating 3.2: TBAF / tetrahydrofuran / 0.5 h / 20 °C 4.1: tetrahydrofuran / 1 h / 20 °C 5.1: BH3*DMS / tetrahydrofuran / 3 h / 2 °C View Scheme
参考文献
Hay, Michael P.; Sykes, Bridget M.; Denny, William A.; O'Connor, Charmian J.
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 19 p. 2759 - 2770
