(S)-3-(2-乙氧基-2-氧代乙基)吗啉-4-羧酸叔丁酯合成路线 （共 6 条）
反应条件
diisobutylaluminium hydride in diethyl ether; toluene T=0°C; 1 h;
参考文献
Pousset, Cyrille; Callens, Roland; Haddad, Mansour; Larcheveque, Marc
Tetrahedron Asymmetry, 2004 , vol. 15, # 21 p. 3407 - 3412
反应条件
Burkholderia cepacia lipase; hydrogenchloride in tetrahydrofuran; phosphate buffer
T=25°C; pH=7; 10 h;
参考文献
Pousset, Cyrille; Callens, Roland; Haddad, Mansour; Larcheveque, Marc
Tetrahedron Asymmetry, 2004 , vol. 15, # 21 p. 3407 - 3412
反应条件
1.1: acetyl chloride / 36 h
1.2: Et3N / CH2Cl2 / 24 h / 20 - 40 °C
2.1: aq. HCl; Burkholderia cepacia lipase / tetrahydrofuran; aq. phosphate buffer / 10 h / 25 °C / pH 7
View Scheme
参考文献
Pousset, Cyrille; Callens, Roland; Haddad, Mansour; Larcheveque, Marc
Tetrahedron Asymmetry, 2004 , vol. 15, # 21 p. 3407 - 3412
反应条件
1.1: Novozym 435(R) / 6 h / pH 7
2.1: acetyl chloride / 36 h
2.2: Et3N / CH2Cl2 / 24 h / 20 - 40 °C
3.1: aq. HCl; Burkholderia cepacia lipase / tetrahydrofuran; aq. phosphate buffer / 10 h / 25 °C / pH 7
View Scheme
参考文献
Pousset, Cyrille; Callens, Roland; Haddad, Mansour; Larcheveque, Marc
Tetrahedron Asymmetry, 2004 , vol. 15, # 21 p. 3407 - 3412
反应条件
1.1: acetyl chloride / 36 h
1.2: Et3N / CH2Cl2 / 24 h / 20 - 40 °C
2.1: aq. HCl; Burkholderia cepacia lipase / tetrahydrofuran; aq. phosphate buffer / 10 h / 25 °C / pH 7
View Scheme
参考文献
Pousset, Cyrille; Callens, Roland; Haddad, Mansour; Larcheveque, Marc
Tetrahedron Asymmetry, 2004 , vol. 15, # 21 p. 3407 - 3412
反应条件
1.1: 1.66 g / aq. HCl / dioxane / 3 h / Heating
2.1: acetyl chloride / 36 h
2.2: Et3N / CH2Cl2 / 24 h / 20 - 40 °C
3.1: aq. HCl; Burkholderia cepacia lipase / tetrahydrofuran; aq. phosphate buffer / 10 h / 25 °C / pH 7
View Scheme
参考文献
Pousset, Cyrille; Callens, Roland; Haddad, Mansour; Larcheveque, Marc
Tetrahedron Asymmetry, 2004 , vol. 15, # 21 p. 3407 - 3412
