(4-溴-2-氟苯基)乙酸合成路线 （共 5 条）
反应条件
iodine; sodium nitrite in methanol; water
T=20°C; 1.5 h;
参考文献
Kiran; Konakahara, Takeo; Sakai, Norio
Synthesis, 2008 , # 15 art. no. F03408SS, p. 2327 - 2332
反应条件
1: With Pd(OPiv)2; [bis(acetoxy)iodo]benzene in α,α,α-trifluorotoluene
T=120°C; Inert atmosphere;
2: With tetrabutyl ammonium fluoride in tetrahydrofuran
T=20°C;
3: With water in tetrahydrofuran
参考文献
Huang, Chunhui; Ghavtadze, Nugzar; Chattopadhyay, Buddhadeb; Gevorgyan, Vladimir
Journal of the American Chemical Society, 2011 , vol. 133, # 44 p. 17630 - 17633
反应条件
1.1: 1H-imidazole / tetrahydrofuran / 20 °C / Inert atmosphere
1.3: 20 °C
2.1: Pd(OPiv)2; [bis(acetoxy)iodo]benzene / α,α,α-trifluorotoluene / 120 °C / Inert atmosphere
2.2: 20 °C
View Scheme
参考文献
Huang, Chunhui; Ghavtadze, Nugzar; Chattopadhyay, Buddhadeb; Gevorgyan, Vladimir
Journal of the American Chemical Society, 2011 , vol. 133, # 44 p. 17630 - 17633
反应条件
1: aqueous HCl; aqueous KI / Diazotization
2: aqueous methanol. HCl
View Scheme
参考文献
Fourneau; Druey
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1934 , vol. 199, p. 870
反应条件
mushroom tyrosinase
Enzymatic reaction; Kinetics;
参考文献
Munoz-Munoz, Jose Luis; Berna, Jose; Garcia-Molina, Maria del Mar; Garcia-Molina, Francisco; Garcia-Ruiz, Pedro Antonio; Varon, Ramon; Rodriguez-Lopez, Jose N.; Garcia-Canovas, Francisco
Biochemical and Biophysical Research Communications, 2012 , vol. 424, # 2 p. 228 - 233
