N-[(7-甲氧基-6-甲基-5,8-二氧代异喹啉-1-基)甲基]-2-氧代丙酰胺合成路线 （共 38 条）
反应条件
salcomine; oxygen in N,N-dimethyl-formamide
T=20°C; 2 h;
参考文献
Kuwabara, Nagako; Hayashi, Hiroyuki; Hiramatsu, Noriko; Choshi, Tominari; Kumemura, Teppei; Nobuhiro, Junko; Hibino, Satoshi
Tetrahedron, 2004 , vol. 60, # 13 p. 2943 - 2952
反应条件
pyridine-2,6-dicarboxylate N-oxide; ammonium cerium(IV) nitrate in water; acetonitrile
T=0 - 2°C;
参考文献
Kubo; Kitahara; Nakahara; Numata
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 1 p. 341 - 343
反应条件
1: 100 percent / cc. HCl, hydrogen / 10percent palladium on carbon / methanol / 2 h / 760 Torr
2: 75 percent / triethylamine, DCC / CHCl3 / 0.25 h / 0 °C
3: 100 percent / hydrogen / 10percent palladium on carbon / methanol / 2 h / 760 Torr
4: 29 percent / 3,5-di-tert-butyl-1,2-benzoquinone / methanol / 18 h / 40 °C
5: 36 percent / CAN, pyridine-2,6-dicarboxylic acid N-oxide / H2O; acetonitrile / 0.5 h
View Scheme
参考文献
Akinori, Kubo; Kitahara, Yoshiyasu; Nakahara, Shinsuke; Iwata, Ryoichi; Numata, Ryuichi
Chemical & Pharmaceutical Bulletin, 1988 , vol. 36, # 11 p. 4355 - 4363
反应条件
nitric acid; silver nitrate
参考文献
Matsuo; Okumura; Tanaka
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 11 p. 4170 - 4174
反应条件
1: 75 percent / triethylamine, DCC / CHCl3 / 0.25 h / 0 °C
2: 100 percent / hydrogen / 10percent palladium on carbon / methanol / 2 h / 760 Torr
3: 29 percent / 3,5-di-tert-butyl-1,2-benzoquinone / methanol / 18 h / 40 °C
4: 36 percent / CAN, pyridine-2,6-dicarboxylic acid N-oxide / H2O; acetonitrile / 0.5 h
View Scheme
参考文献
Akinori, Kubo; Kitahara, Yoshiyasu; Nakahara, Shinsuke; Iwata, Ryoichi; Numata, Ryuichi
Chemical & Pharmaceutical Bulletin, 1988 , vol. 36, # 11 p. 4355 - 4363
反应条件
1: 89 percent / zinc / 0.5 h / Ambient temperature
2: 79 percent / 80percent m-chloroperoxybenzoic acid / CH2Cl2 / 12 h / Ambient temperature
3: 84 percent / various solvent(s) / 50-60 degC, 20 min, rt. 20 h
4: cc. HCl, hydrogen / 10percent palladium on carbon / methanol / 3 h / 760 Torr
5: α,α-dichloromethyl methyl ether / 0.17 h / 50 °C
View Scheme
参考文献
Akinori, Kubo; Kitahara, Yoshiyasu; Nakahara, Shinsuke; Iwata, Ryoichi; Numata, Ryuichi
Chemical & Pharmaceutical Bulletin, 1988 , vol. 36, # 11 p. 4355 - 4363
反应条件
1: 79 percent / 80percent m-chloroperoxybenzoic acid / CH2Cl2 / 12 h / Ambient temperature
2: 84 percent / various solvent(s) / 50-60 degC, 20 min, rt. 20 h
3: cc. HCl, hydrogen / 10percent palladium on carbon / methanol / 3 h / 760 Torr
4: α,α-dichloromethyl methyl ether / 0.17 h / 50 °C
View Scheme
参考文献
Akinori, Kubo; Kitahara, Yoshiyasu; Nakahara, Shinsuke; Iwata, Ryoichi; Numata, Ryuichi
Chemical & Pharmaceutical Bulletin, 1988 , vol. 36, # 11 p. 4355 - 4363
反应条件
1: cc. HCl, hydrogen / 10percent palladium on carbon / methanol / 3 h / 760 Torr
2: α,α-dichloromethyl methyl ether / 0.17 h / 50 °C
View Scheme
参考文献
Akinori, Kubo; Kitahara, Yoshiyasu; Nakahara, Shinsuke; Iwata, Ryoichi; Numata, Ryuichi
Chemical & Pharmaceutical Bulletin, 1988 , vol. 36, # 11 p. 4355 - 4363
反应条件
1: 96 percent / benzoyl chloride / H2O / 0.5 h / Ambient temperature
2: 100 percent / cc. HCl, hydrogen / 10percent palladium on carbon / methanol / 2 h / 760 Torr
3: 75 percent / triethylamine, DCC / CHCl3 / 0.25 h / 0 °C
4: 100 percent / hydrogen / 10percent palladium on carbon / methanol / 2 h / 760 Torr
5: 29 percent / 3,5-di-tert-butyl-1,2-benzoquinone / methanol / 18 h / 40 °C
6: 36 percent / CAN, pyridine-2,6-dicarboxylic acid N-oxide / H2O; acetonitrile / 0.5 h
View Scheme
参考文献
Akinori, Kubo; Kitahara, Yoshiyasu; Nakahara, Shinsuke; Iwata, Ryoichi; Numata, Ryuichi
Chemical & Pharmaceutical Bulletin, 1988 , vol. 36, # 11 p. 4355 - 4363
反应条件
dichloromethoxy methane in neat (no solvent)
T=40 - 50°C; 0.5 h;
参考文献
Kubo, Akinori; Nakahara, Shinsuke; Iwata, Ryoichi; Takahashi, Katsuhiro; Arai, Tadashi
Tetrahedron Letters, 1980 , vol. 21, p. 3207 - 3208
