N-[(7-甲氧基-6-甲基-5,8-二氧代异喹啉-1-基)甲基]-2-氧代丙酰胺合成路线 （共 38 条）
反应条件
1.1: PPh3 / benzene / 12 h / 20 °C
1.2: 45 percent / benzene / 0.08 h / 20 °C
2.1: 91 percent / H2 / Pd/C / ethanol / 2 h / 20 °C
3.1: 85 percent / salcomine; O2 / dimethylformamide / 2 h / 20 °C
View Scheme
参考文献
Kuwabara, Nagako; Hayashi, Hiroyuki; Hiramatsu, Noriko; Choshi, Tominari; Kumemura, Teppei; Nobuhiro, Junko; Hibino, Satoshi
Tetrahedron, 2004 , vol. 60, # 13 p. 2943 - 2952
反应条件
1: 91 percent / H2 / Pd/C / ethanol / 2 h / 20 °C
2: 85 percent / salcomine; O2 / dimethylformamide / 2 h / 20 °C
View Scheme
参考文献
Kuwabara, Nagako; Hayashi, Hiroyuki; Hiramatsu, Noriko; Choshi, Tominari; Kumemura, Teppei; Nobuhiro, Junko; Hibino, Satoshi
Tetrahedron, 2004 , vol. 60, # 13 p. 2943 - 2952
反应条件
1.1: 81 percent / NaN3 / H2O; dioxane / 1 h / 60 °C
2.1: PPh3 / benzene / 12 h / 20 °C
2.2: 45 percent / benzene / 0.08 h / 20 °C
3.1: 91 percent / H2 / Pd/C / ethanol / 2 h / 20 °C
4.1: 85 percent / salcomine; O2 / dimethylformamide / 2 h / 20 °C
View Scheme
参考文献
Kuwabara, Nagako; Hayashi, Hiroyuki; Hiramatsu, Noriko; Choshi, Tominari; Kumemura, Teppei; Nobuhiro, Junko; Hibino, Satoshi
Tetrahedron, 2004 , vol. 60, # 13 p. 2943 - 2952
反应条件
1: 100 percent / hydrogen / 10percent palladium on carbon / methanol / 2 h / 760 Torr
2: 29 percent / 3,5-di-tert-butyl-1,2-benzoquinone / methanol / 18 h / 40 °C
3: 36 percent / CAN, pyridine-2,6-dicarboxylic acid N-oxide / H2O; acetonitrile / 0.5 h
View Scheme
参考文献
Akinori, Kubo; Kitahara, Yoshiyasu; Nakahara, Shinsuke; Iwata, Ryoichi; Numata, Ryuichi
Chemical & Pharmaceutical Bulletin, 1988 , vol. 36, # 11 p. 4355 - 4363
反应条件
1: 84 percent / various solvent(s) / 50-60 degC, 20 min, rt. 20 h
2: cc. HCl, hydrogen / 10percent palladium on carbon / methanol / 3 h / 760 Torr
3: α,α-dichloromethyl methyl ether / 0.17 h / 50 °C
View Scheme
参考文献
Akinori, Kubo; Kitahara, Yoshiyasu; Nakahara, Shinsuke; Iwata, Ryoichi; Numata, Ryuichi
Chemical & Pharmaceutical Bulletin, 1988 , vol. 36, # 11 p. 4355 - 4363
反应条件
1: 29 percent / 3,5-di-tert-butyl-1,2-benzoquinone / methanol / 18 h / 40 °C
2: 36 percent / CAN, pyridine-2,6-dicarboxylic acid N-oxide / H2O; acetonitrile / 0.5 h
View Scheme
参考文献
Akinori, Kubo; Kitahara, Yoshiyasu; Nakahara, Shinsuke; Iwata, Ryoichi; Numata, Ryuichi
Chemical & Pharmaceutical Bulletin, 1988 , vol. 36, # 11 p. 4355 - 4363
反应条件
1: 65 percent / 15percent H2SO4 / dioxane; acetone / 0.83 h / 60 °C
2: 39 percent / argentous oxide / 15 h / Ambient temperature
View Scheme
参考文献
Akinori, Kubo; Kitahara, Yoshiyasu; Nakahara, Shinsuke; Iwata, Ryoichi; Numata, Ryuichi
Chemical & Pharmaceutical Bulletin, 1988 , vol. 36, # 11 p. 4355 - 4363
反应条件
silver(l) oxide
15 h; Ambient temperature;
参考文献
Akinori, Kubo; Kitahara, Yoshiyasu; Nakahara, Shinsuke; Iwata, Ryoichi; Numata, Ryuichi
Chemical & Pharmaceutical Bulletin, 1988 , vol. 36, # 11 p. 4355 - 4363
