hydrogenchloride; acetic acid T=65°C; 2.5 h;

1: 12.9 percent / 0.25 h / 250 °C 2: 26 percent / HOAc, aq. ceric ammonium sulfate / benzene / 96 h / 40 - 45 °C 3: 90 percent / conc. HCl, HOAc / 2.5 h / 65 °C View Scheme

1: 12.9 percent / 0.25 h / 250 °C 2: 26 percent / HOAc, aq. ceric ammonium sulfate / benzene / 96 h / 40 - 45 °C 3: 90 percent / conc. HCl, HOAc / 2.5 h / 65 °C View Scheme

1: 26 percent / HOAc, aq. ceric ammonium sulfate / benzene / 96 h / 40 - 45 °C 2: 90 percent / conc. HCl, HOAc / 2.5 h / 65 °C View Scheme

1: 79 percent / N-bromoacetamid (NBA), aq. HCl / tetrahydrofuran / 1 h / 0 - 5 °C 2: pyridine / 16 h / 0 - 5 °C 3: 1 percent / NaOMe / tetrahydrofuran / 45 h / 0 - 5 °C View Scheme

1: 79 percent / N-bromoacetamid (NBA), aq. HCl / tetrahydrofuran / 1 h / 0 - 5 °C 2: pyridine / 16 h / 0 - 5 °C 3: 1 percent / NaOMe / tetrahydrofuran / 45 h / 0 - 5 °C 4: 10 percent / aq. NaOCl / tetrabutylammonium hydrogen sulfate / CHCl3 / 5 h / Ambient temperature View Scheme