5-氰基-吡啶-2-羧酸甲酯合成路线 （共 5 条）
反应条件
1: With ethanol; sodium hydroxide T=20°C; 0.166667 h; 2: With hydrogenchloride; water in ethanol
参考文献
EISAI RandD MANAGEMENT CO., LTD.
Patent: US2010/93999 A1, 2010 ;
Location in patent: Page/Page column 35 ;
US 20100093999 A1
反应条件
copper (I) cyanide in 1-methyl-pyrrolidin-2-one
T=170°C; 1.5 h;
参考文献
Eisai RandD Management CO., LTD.; MOTOKI, Takafumi; KANEKO, Toshihiko; YAMAMOTO, Noboru; KHAN, Afzal
Patent: WO2010/13794 A1, 2010 ;
Location in patent: Page/Page column 86-87 ;
WO 2010/013794 A1
反应条件
in 1-methyl-pyrrolidin-2-one
T=170°C; 1.5 h;
参考文献
EISAI RandD MANAGEMENT CO., LTD.
Patent: US2010/93999 A1, 2010 ;
Location in patent: Page/Page column 35 ;
US 20100093999 A1
反应条件
pyridine; trichlorophosphate
T=70°C; 0.5 h;
参考文献
Isoda, Sumiro; Yamaguchi, Hitoshi; Satoh, Yoshinari; Miki, Tosaku; Hirata, Miyoshi
Chemical & Pharmaceutical Bulletin, 1980 , vol. 28, # 5 p. 1408 - 1414
反应条件
1: H2, conc. HCl / 5 percent Pd-C / methanol / 10 h / Ambient temperature
2: 4 N NaOH / 2 h / Heating
View Scheme
参考文献
Isoda, Sumiro; Yamaguchi, Hitoshi; Satoh, Yoshinari; Miki, Tosaku; Hirata, Miyoshi
Chemical & Pharmaceutical Bulletin, 1980 , vol. 28, # 5 p. 1408 - 1414
