5-甲基-2-嘧啶羧酸甲酯合成路线 （共 2 条）
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine in acetonitrile
T=20 - 100°C; Inert atmosphere;
参考文献
ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew, J.; BURSAVICH, Matthew, Gregory
Patent: WO2013/142269 A1, 2013 ;
Location in patent: Paragraph 0613; 0614; 0615 ;
反应条件
1: 12 percent / NBS, benzoyl peroxide / benzene / 5 h / Heating
2: 64 percent / dimethylformamide / 4 h / 50 - 60 °C
3: 0.5 N NaOH / 1 h
4: 25 percent / 80 percent N2H4*H2O / methanol / 40 h / Heating
View Scheme
参考文献
Isoda, Sumiro; Yamaguchi, Hitoshi; Satoh, Yoshinari; Miki, Tosaku; Hirata, Miyoshi
Chemical & Pharmaceutical Bulletin, 1980 , vol. 28, # 5 p. 1408 - 1414
