1-(4-氯苯基)-6,7-二甲氧基-3,4-二氢异喹啉合成路线 （共 7 条）
反应条件
1,10-Phenanthroline-5,6-dione; oxygen; pyridinium p-toluenesulfonate; zinc(II) iodide in acetonitrile
T=20°C; 24 h;
参考文献
Wendlandt, Alison E.; Stahl, Shannon S.
Journal of the American Chemical Society, 2014 , vol. 136, # 1 p. 506 - 512
反应条件
1: With trichlorophosphate in toluene
T=140°C; Bischler-Napieralski reaction; 0.5 h; Microwave irradiation;
2: With sodium hydroxide in water
pH=8; Cooling;
参考文献
Awuah, Emelia; Capretta, Alfredo
Journal of Organic Chemistry, 2010 , vol. 75, # 16 p. 5627 - 5634
反应条件
P2O5; trichlorophosphate in xylene
3 h; Heating; Yield given;
参考文献
Cortes Cortes; Cortes Romero; Gutierrez Ramirez
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 6 p. 1425 - 1427
反应条件
1: 20percent aq. sodium hydroxide / diethyl ether / Ambient temperature
2: phosphorus pentoxide, phosphorus oxychloride / xylene / 3 h / Heating
View Scheme
参考文献
Cortes Cortes; Cortes Romero; Gutierrez Ramirez
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 6 p. 1425 - 1427
反应条件
1: 20percent aq. sodium hydroxide / diethyl ether / Ambient temperature
2: phosphorus pentoxide, phosphorus oxychloride / xylene / 3 h / Heating
View Scheme
参考文献
Cortes Cortes; Cortes Romero; Gutierrez Ramirez
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 6 p. 1425 - 1427
反应条件
1: methanol / 16 h / 20 °C
2: trifluoroacetic acid / 3 h / |Reflux
3: 1,10-Phenanthroline-5,6-dione; zinc(II) iodide; pyridinium p-toluenesulfonate; oxygen / acetonitrile / 24 h / 20 °C
View Scheme
参考文献
Wendlandt, Alison E.; Stahl, Shannon S.
Journal of the American Chemical Society, 2014 , vol. 136, # 1 p. 506 - 512
反应条件
1.1: methanol / 16 h / 20 °C
1.2: 3 h / |Reflux
2.1: 1,10-Phenanthroline-5,6-dione; zinc(II) iodide; pyridinium p-toluenesulfonate; oxygen / acetonitrile / 24 h / 20 °C
View Scheme
参考文献
Wendlandt, Alison E.; Stahl, Shannon S.
Journal of the American Chemical Society, 2014 , vol. 136, # 1 p. 506 - 512
