7-甲氧基-3-甲基-2,3,4,5-四氢-1H-苯并[d]氮杂卓合成路线 （共 5 条）
反应条件
1: With sodium tris(acetoxy)borohydride in dichloromethane; water
T=20°C; 2 h;
2: With sodium hydroxide in dichloromethane; water
pH=10;
参考文献
GLAXO GROUP LIMITED
Patent: WO2005/14578 A1, 2005 ;
Location in patent: Page/Page column 33 ;
WO 2005/014578 A1
反应条件
sodium tris(acetoxy)borohydride in water; 1,2-dichloro-ethane
T=20°C; 2 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2005/25576 A1, 2005 ;
Location in patent: Page/Page column 23-24 ;
WO 2005/025576 A1
反应条件
sodium hydroxide; formic acid
参考文献
Pennwalt Corporation
Patent: US4210749 A1, 1980 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Takeuchi, Kumiko; Holloway, William G.; Mitch, Charles H.; Quimby, Steven J.; McKinzie, Jamie H.; Suter, Todd M.; Statnick, Michael A.; Surface, Peggy L.; Emmerson, Paul J.; Thomas, Elizabeth M.; Siegel, Miles G.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 24 p. 6841 - 6846
反应条件
1-chloroethyl chlorocarbonate
参考文献
Takeuchi, Kumiko; Holloway, William G.; Mitch, Charles H.; Quimby, Steven J.; McKinzie, Jamie H.; Suter, Todd M.; Statnick, Michael A.; Surface, Peggy L.; Emmerson, Paul J.; Thomas, Elizabeth M.; Siegel, Miles G.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 24 p. 6841 - 6846
