1-(氯乙酰基)-2-(三氟乙酰基)肼合成路线 （共 6 条）
反应条件
1: ethyl-α,α,α-trifluoroacetate With hydrazine hydrate in acetonitrile T=10 - 20°C; 2: chloroacetyl chloride With sodium hydroxide in water; acetonitrile T=0 - 18°C;
参考文献
DR. REDDY'S LABORATORIES LIMITED; DR. REDDY'S LABORATORIES, INC.
Patent: WO2009/85990 A2, 2009 ;
Location in patent: Page/Page column 26 ;
反应条件
sodium hydroxide in water; acetonitrile T=7 - 25°C; 4.16667 h;
参考文献
MERCK and CO., INC.
Patent: WO2004/83212 A1, 2004 ;
Location in patent: Page 7-8 ;
反应条件
1: ethyl-α,α,α-trifluoroacetate With hydrazine in water; acetonitrile T=14 - 25°C; 2 h; 2: chloroacetyl chloride With sodium hydroxide in water; acetonitrile T=7 - 16°C; 2.16667 h;
参考文献
WO2005/97733 A1, ;
Page/Page column 19-21 ;
反应条件
sodium hydroxide in water; acetonitrile T=7 - 16°C; 2.16667 h;
参考文献
WO2006/9886 A1, ;
Page/Page column 41 ;
WO 2006/009886 A1
反应条件
in chloroform; toluene
反应条件
trichlorophosphate in acetonitrile T=80°C; 24 h;
参考文献
MERCK and CO., INC.
Patent: WO2007/50485 A2, 2007 ;
Location in patent: Page/Page column 33 ;
WO 2007/050485 A2
